3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- CAS No.
- 294675-79-9
- Chemical Name:
- 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- Synonyms
- ERK INHIBITOR;2,4-Thiazolidinedione, 3-(2-aminoethyl)-5-[(4-ethoxyphenyl)methylene]-;3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE
- CBNumber:
- CB3797565
- Molecular Formula:
- C14H16N2O3S
- Molecular Weight:
- 292.35
- MDL Number:
- MFCD09038681
- MOL File:
- Mol file
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A6355 | 3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione hydrochloride powder, ≥98% (HPLC) | 294675-79-9 | 5mg | $134 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | CHM0116130 | 3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE 95.00% | 294675-79-9 | 5MG | $698.52 | 2021-12-16 | Buy |
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is an extracellular signal-regulated kinase (ERK) docking domain inhibitor. ERK inhibitors have been used to study traumatic brain injuries.
Biochem/physiol Actions
3-(2-Aminoethyl)-5-((4-ethoxyphenyl)methylene)-2,4-thiazolidinedione is extracellular signal-regulated kinase (ERK) docking domain inhibitor. Inhibits ERK binding rather then ERK activity at the ATP domain. IC50 = 25 μM in HeLa, A549, and SUM-159 tumor cells. Currently, no specific inhibitors of the ERK proteins exist. Preferentially binds to ERK2 with a Kd of ~5 μM and prevents its interaction with protein substrates. Shown to block ERK-mediated phosphorylation of ribosomal S6 kinase-1 (RSK-1) and ternary complex factor Elk-1, but exhibits little effect on ERK1/2 phosphorylation by MEK1/2.
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-AMINOETHYL)-5-((4-ETHOXYPHENYL)METHYLENE)-2,4-THIAZOLIDINEDIONE HYDROCHLORIDE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Haoran Biotechnology Co., Ltd. | -- | 470003480@QQ.COM | CHINA | 6968 | 58 |
| Shanghai Yaoyun Biological Technology Co., Ltd. | -- | 912529879@qq.com | CHINA | 6852 | 58 |
| Absin Bioscience Inc. | -- | chenjw@absin.cn | CHINA | 6661 | 58 |
| Shanghai Weiwei Biological Technology Co., Ltd. | -- | sales@wheybio.com | CHINA | 4398 | 58 |
| Morning Student Science and Technology (Guangzhou) Co., Ltd. | -- | chenxue_gz@163.com | CHINA | 6618 | 58 |
| Beijing Zhijie Fangyuan Technology Co., Ltd. | -- | 15810200961@163.com | CHINA | 6984 | 58 |
| Shanghai Jijin Chemical Technology Co., Ltd. | -- | jijinhuaxue@sina.com | CHINA | 6617 | 58 |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | -- | info@zzsrm.com | CHINA | 6846 | 58 |
| Shanghai Benrui Biotechnology Co., Ltd. | -- | john.st@163.com | CHINA | 1472 | 58 |
| Riedel-de Haen AG | -- | United States | 6825 | 87 |