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Pirtobrutinib

Pirtobrutinib Structure
Pirtobrutinib structure
CAS No.
2101700-15-4
Chemical Name:
Pirtobrutinib
Synonyms
Pirtobrutinib;Pirtobrutinib (LOXO-305);loxo-305;LY 3527727;BTK inhibitor 16;Florfenicol Impurity 16;LOXO-305，LY 3527727，Pirtobrutinib;(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-;LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation
CBNumber:
CB38153637
Molecular Formula:
C22H21F4N5O3
Molecular Weight:
479.43
MDL Number:
MFCD34179491
MOL File:
2101700-15-4.mol
Last updated:2024-07-02 08:55:07
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Pirtobrutinib Properties

Boiling point 619.2±55.0 °C(Predicted)
Density 1.44±0.1 g/cm3(Predicted)
storage temp. 4°C, stored under nitrogen
solubility DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
form A solid
pka 13.32±0.46(Predicted)
color White to yellow
FDA UNII JNA39I7ZVB

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H373-H360
Precautionary statements  P260-P314-P501

Pirtobrutinib Chemical Properties,Uses,Production

Description

Pirtobrutinib, or LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover.

Pirtobrutinib Preparation Products And Raw materials

Raw materials

Preparation Products

Pirtobrutinib Suppliers

Global( 73)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Joiny Pharmaceutical Co.,LTD 		+8613681955282 gyd@joiny-pharma.com China 249 58
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 16208 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32760 60
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
Henan Alfa Chemical Co., Ltd 		+8618339805032 alfa4@alfachem.cn China 13141 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc. 		+1-781-999-5354 support@targetmol.com United States 19973 58
Chemtour Biotech Co., Ltd 		+8617327281506 market@chemtour.com China 1460 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Supplier Advantage
Shanghai Joiny Pharmaceutical Co.,LTD 		58
Shanghai Daken Advanced Materials Co.,Ltd 		58
ATK CHEMICAL COMPANY LIMITED 		60
Zhejiang J&C Biological Technology Co.,Limited 		58
Henan Alfa Chemical Co., Ltd 		58
InvivoChem 		58
Nantong HI-FUTURE Biology Co., Ltd. 		58
TargetMol Chemicals Inc. 		58
Chemtour Biotech Co., Ltd 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58

View Lastest Price from Pirtobrutinib manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pirtobrutinib pictures 2024-06-14 Pirtobrutinib
2101700-15-4
 US $0.00 / kg 1kg 99% 200kg Shanghai Joiny Pharmaceutical Co.,LTD
  • Pirtobrutinib pictures
  • Pirtobrutinib
    2101700-15-4
  • US $0.00 / kg
  • 99%
  • Shanghai Joiny Pharmaceutical Co.,LTD

Pirtobrutinib Spectrum

LOXO-305(2101700-15-4)1HNMR
LY 3527727 (S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide 1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]- Pirtobrutinib Pirtobrutinib (LOXO-305) loxo-305 (S)-5-Amino-3-{4-[(5-fluoro-2-methoxy-benzoylamino)-methyl]-phenyl}-1-(2,2,2-trifluoro-1-methyl-ethyl)-1H-pyrazole-4-carboxylic acid amide LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation Florfenicol Impurity 16 LOXO-305，LY 3527727，Pirtobrutinib BTK inhibitor 16 2101700-15-4 api