1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
- CAS No.
- 210580-75-9
- Chemical Name:
- 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
- Synonyms
- AL-34662;AL 34497;1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL;1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-
- CBNumber:
- CB3822775
- Molecular Formula:
- C10H13N3O
- Molecular Weight:
- 191.23
- MDL Number:
- MFCD09031487
- MOL File:
- 210580-75-9.mol
| Melting point | 170-172 °C(Solv: dichloromethane (75-09-2)) |
|---|---|
| Boiling point | 372.8±22.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | ≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 9.30±0.40(Predicted) |
| FDA UNII | 1Q6O947QMH |
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10011546 | AL 34662 ≥98% | 210580-75-9 | 1mg | $13 | 2023-06-20 | Buy |
| Cayman Chemical | 10011546 | AL 34662 ≥98% | 210580-75-9 | 5mg | $51 | 2023-06-20 | Buy |
| Cayman Chemical | 10011546 | AL 34662 ≥98% | 210580-75-9 | 10mg | $87 | 2023-06-20 | Buy |
| Cayman Chemical | 10011546 | AL 34662 ≥98% | 210580-75-9 | 50mg | $376 | 2023-06-20 | Buy |
| ApexBio Technology | C5271 | AL34662 | 210580-75-9 | 50mg | $437 | 2021-12-16 | Buy |
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Chemical Properties,Uses,Production
Biological Activity
al 34662 is a potent 5-ht2 receptor agonist.serotonin (5-hydroxytryptamine; 5-ht) is a major neurotransmitter in the central nervous system (cns) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs.
in vitro
al-34662 exhibited a high affinity for the rat and human 5-ht2 receptor and for cloned human 5-ht2a-c receptors. al-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. al-34662 also mobilized intracellular ca2+ in h-cm and h-tm cells, being a full agonist like 5-ht itself. al-34662's effects in the h-cm cells were potently antagonized by 5-ht2a-antagonist m-100907, but weakly by 5-ht2b-antagonist, 5-ht2b/c- antagonist and 5-ht2c antagonist. moreover, it was found that the (r)-enantiomer (al-34707) and the racemate (al-34497) were less potent and/or efficacious than al-34662 in all of these assays [1].
in vivo
al-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. it efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1].
IC 50
0.8-1.5 nm for rat and human 5-ht2 receptor
References
[1] sharif na, mclaughlin ma, kelly cr. al-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. j ocul pharmacol ther. 2007 feb;23(1):1-13.
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Preparation Products And Raw materials
Raw materials
Preparation Products
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Suzhou Chenrui Biotechnology Co. LTD | 17625585511 | 1580084073@qq.com | China | 509 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2988 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |