| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:AL 34662
CAS:210580-75-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
|
| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
CAS:210580-75-9
Purity:98% Package:10mg; 50mg Remarks:Medbio
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1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL manufacturers
- AL 34662
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- $35.00 / 1mg
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2024-11-17
- CAS:210580-75-9
- Min. Order:
- Purity: 99.77%
- Supply Ability: 10g
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| | 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Basic information |
| | 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Chemical Properties |
| Melting point | 170-172 °C(Solv: dichloromethane (75-09-2)) | | Boiling point | 372.8±22.0 °C(Predicted) | | density | 1.31±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide | | form | crystalline solid | | pka | 9.30±0.40(Predicted) | | color | White to off-white |
| | 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Usage And Synthesis |
| Biological Activity | al 34662 is a potent 5-ht2 receptor agonist.serotonin (5-hydroxytryptamine; 5-ht) is a major neurotransmitter in the central nervous system (cns) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs. | | in vitro | al-34662 exhibited a high affinity for the rat and human 5-ht2 receptor and for cloned human 5-ht2a-c receptors. al-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. al-34662 also mobilized intracellular ca2+ in h-cm and h-tm cells, being a full agonist like 5-ht itself. al-34662's effects in the h-cm cells were potently antagonized by 5-ht2a-antagonist m-100907, but weakly by 5-ht2b-antagonist, 5-ht2b/c- antagonist and 5-ht2c antagonist. moreover, it was found that the (r)-enantiomer (al-34707) and the racemate (al-34497) were less potent and/or efficacious than al-34662 in all of these assays [1]. | | in vivo | al-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. it efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1]. | | IC 50 | 0.8-1.5 nm for rat and human 5-ht2 receptor | | references | [1] sharif na, mclaughlin ma, kelly cr. al-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. j ocul pharmacol ther. 2007 feb;23(1):1-13. |
| | 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Preparation Products And Raw materials |
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