DSHN >=98% (HPLC)
- CAS No.
- 313952-63-5
- Chemical Name:
- DSHN >=98% (HPLC)
- Synonyms
- DSHN >=98% (HPLC);2-Naphthalenecarboxylic acid, 5-[(diethylamino)sulfonyl]-3-hydroxy-
- CBNumber:
- CB38378797
- Molecular Formula:
- C15H17NO5S
- Molecular Weight:
- 323.36
- MDL Number:
- MOL File:
- 313952-63-5.mol
DSHN >=98% (HPLC) Chemical Properties,Uses,Production
Description
DSHN is a novel activator of small heterodimer partner (SHP, NR0B2). DSHN transcriptionally activates SHP mRNA, but also stabilizes the SHP protein by preventing its ubiquitination and degradation.
Definition
ChEBI: 5-(diethylsulfamoyl)-3-hydroxy-2-naphthalenecarboxylic acid is a member of naphthalenes and a sulfonic acid derivative.
in vivo
DSHN transcriptionally activated Shp mRNA, but also stabilized the SHP protein by preventing its ubiquitination and degradation. Second, this study identified Ccl2 as a new SHP target gene by RNA-seq. This study showed that activation of SHP by DSHN repressed Ccl2 expression and secretion by inhibiting p65 activation of CCL2 promoter activity, as demonstrated in vivo in Shp-/- mice and in vitro in HCC cells with SHP overexpression and knockdown._x000D_ _x000D_ Reference: Mol Cancer Ther. 2016 Oct;15(10):2294-2301. https://pubmed.ncbi.nlm.nih.gov/27486225/
target
DSHN is a novel activator of small heterodimer partner (SHP, NR0B2).
DSHN >=98% (HPLC) Preparation Products And Raw materials
Raw materials
Preparation Products
DSHN >=98% (HPLC) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Energy Chemical | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |