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3-Chloropropiononitrile

CAS No.
542-76-7
Chemical Name:
3-Chloropropiononitrile
Synonyms
3-Chloropropanenitrile;3-CHLOROPROPIONITRILE;CH2ClCH2CN;usafa-8798;USAF a-8798;3-Chlorpropannitril;rcrawastenumberp027;3-choropropionitrile;3-Chloropropuinitrile;3-chloro-propionitril
CBNumber:
CB3853791
Molecular Formula:
C3H4ClN
Molecular Weight:
89.52
MDL Number:
MFCD00001952
MOL File:
542-76-7.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:30

3-Chloropropiononitrile Properties

Melting point ?52-?50 °C (lit.)
Boiling point 174-176 °C (lit.)
Density 1.144 g/mL at 25 °C (lit.)
refractive index n20/D 1.438(lit.)
Flash point 168 °F
storage temp. Store below +30°C.
solubility 45g/l
form clear liquid
color Colorless to Almost colorless
Water Solubility 4.50 g/100 mL
Merck 14,2160
BRN 1098454
CAS DataBase Reference 542-76-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 61N7S4SZ2Q
NIST Chemistry Reference Cl(CH2)2CN(542-76-7)
EPA Substance Registry System 3-Chloropropionitrile (542-76-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H300-H315-H319
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  T+
Risk Statements  23-28
Safety Statements  36/37/39-45
RIDADR  UN 3276 6.1/PG 2
WGK Germany  3
RTECS  UG1400000
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29269095
Hazardous Substances Data 542-76-7(Hazardous Substances Data)
Toxicity LD50 orally in mice, rats: 9, 100 mg/kg, Fassett in Industrial Hygiene and Toxicology vol. 2, F. A. Patty, Ed. (Interscience, New York, 2nd ed., 1962) pp 2025-2026
NFPA 704
2
2 1

3-Chloropropiononitrile price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C69101 3-Chloropropionitrile 98% 542-76-7 500g $497 2023-06-20 Buy
Sigma-Aldrich C69101 3-Chloropropionitrile 98% 542-76-7 100g $116 2023-01-07 Buy
TCI Chemical C0277 3-Chloropropionitrile >98.0%(GC) 542-76-7 25mL $36 2024-03-01 Buy
TCI Chemical C0277 3-Chloropropionitrile >98.0%(GC) 542-76-7 500mL $240 2024-03-01 Buy
Alfa Aesar L05902 3-Chloropropionitrile, 98% 542-76-7 25g $34.65 2024-03-01 Buy
Product number Packaging Price Buy
C69101 500g $497 Buy
C69101 100g $116 Buy
C0277 25mL $36 Buy
C0277 500mL $240 Buy
L05902 25g $34.65 Buy

3-Chloropropiononitrile Chemical Properties,Uses,Production

Description

3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor. Molecular weight =89.53;Boiling point=175-176℃ (decomposes); Flashpoint =76℃. Hazard Identification (based on NFPA-704 MRating System): Flammability 2, Reactivity 1

Chemical Properties

3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor

Uses

3-Chloropropionitrile is used in pharmaceutical and polymer synthesis.

Uses

In pharmaceutical and polymer synthesis. Combines the reactivity of a nitrile and an alkyl halide. Because of the cyano group the chlorine atom is more reactive than in ordinary alkyl halides.

Production Methods

3-Chloropropionitrile [542-76-7], 3-chloropropanenitrile, b-chloropropionitrile, ClCH2 CH2CN, Mr 89.53, mp-51℃, bp 175 –176℃ (101.3 kPa), n20D 1.4360, d204 1.1573, is a colorless liquid miscible with acetone, benzene, ethanol and diethyl ether. It can be obtained by hydrochlorination of acrylonitrile with hydrochloric acid [49] and is used as an organic intermediate in the synthesis of the H2-receptor famotidine.

General Description

Colorless liquid with a characteristic acrid odor. Used in pharmaceutical and polymer synthesis.

Reactivity Profile

Toxic gas (hydrogen chloride) is released when the compound is heated above 266 F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat. [EPA, 1998].

Hazard

Toxic by ingestion, inhalation, and skin contact. Combustible.

Health Hazard

Toxic effects are a result of systemic cyanide poisoning. (Non-Specific -- Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of potassium cyanide). Cause of death is lack of oxygen to the body's cells (especially the brain and heart) as a result of the chemical inhibiting cell enzymes.

Fire Hazard

Toxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.

Potential Exposure

This material is used in pharmaceutical manufacture and in polymer synthesis.

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Use amyl nitrate capsules if symptoms develop. All areaemployees should be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidotekit should be kept in the immediate work area and must berapidly available. Kit ingredients should be replaced every12 years to ensure freshness. Persons trained in the use ofthis kit, oxygen use, and CPR must be quickly available.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Before entering confined space where 3-chloropropionitrile may be present, check to make sure that an explosive concentration does not exist. Store in tightly closedcontainers in a cool, well-ventilated area. Metal containersinvolving the transfer of this chemical should be groundedand bonded. Where possible, automatically pump liquidfrom drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use onlynonsparking tools and equipment, especially when openingand closing containers of this chemical. Sources of ignition,such as smoking and open flames, are prohibited where thischemical is used, handled, or stored in a manner that couldcreate a potential fire or explosion hazard.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Incompatibilities

Contact with strong oxidizers may cause a fire and explosion hazard

98-88-4
109-78-4
542-76-7
5325-95-1
Synthesis of 3-Chloropropiononitrile from Benzoyl chloride and 3-Hydroxypropionitrile
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View Lastest Price from 3-Chloropropiononitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Chloropropiononitrile pictures 2021-07-02 3-Chloropropiononitrile
542-76-7
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
3-Chloropropiononitrile pictures 2019-07-06 3-Chloropropiononitrile
542-76-7
US $100.00 / KG 1KG 98% 100KG Career Henan Chemical Co
3-chloro-propanenitril 3-chloro-Propanenitrile 3-Chloropropanenitrile-Chloroethylcyanide 3-Chloropropanonitrile 3-chloro-propionitril 3-Chloropropuinitrile 3-Chlorpropannitril CH2ClCH2CN Propanenitrile, 3-chloro- Propionitrile, 3-chloro- propionitrile,3-chloro- Rcra waste number P027 rcrawastenumberp027 USAF a-8798 usafa-8798 beta-Chloropropiontrile PROPIONITRILE, 3-CHLORO- (3-CHLOROPROPIONITRILE 3-Chloropropionitrile 542-76-7 3-Chloropropionitrile,>98% 3-choropropionitrile b-Chloropropionitrile β- Chloroethyl cyanide 3-CHLOROPROPIONITRILE FOR SYNTHESIS Chloropropionitrile, 3- β-Chloropropylnitrile CHLORO-3-PROPIONITRILE β-Chloropropiononitrile BETA-CHLOROPROPIONITRILE β-Chloropropionitrile 3-CHLOROPROPIONIC ACID NITRILE 3-CHLOROPROPIONONITRILE 1-Chloro-2-cyanoethane 3-Chloropropionitrile > 3-Chloropropanenitrile 3-CHLOROPROPIONITRILE Famotidine Impurity 19 542-76-7 C3H4ClN C3H4NCl ClCH2CH2CN NITRILE Building Blocks C1 to C5 Organic Building Blocks Nitrogen Compounds Cyanides/Nitriles API Intermediate C1 to C5 Cyanides/Nitriles Nitrogen Compounds Organics