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guanidine

CAS No.
113-00-8
Chemical Name:
guanidine
Synonyms
imidourea;Carbamidine;carbamamidine;Guanidine 98%;Guanidinebase;Diaminomethanimine;Ribavirin Impurity T;Guanidine, free base;Metformin Impurity 33;Metformin Impurity 33 Monomer
CBNumber:
CB3874769
Molecular Formula:
CH5N3
Molecular Weight:
59.07
MDL Number:
MOL File:
113-00-8.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:30

guanidine Properties

Melting point ~50°
Boiling point 82.3°C (rough estimate)
Density 1.6000 (rough estimate)
refractive index 1.5950 (estimate)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka pKa ~12.5(at 25℃)
color White
Indirect Additives used in Food Contact Substances GUANIDINE
FDA UNII JU58VJ6Y3B
EPA Substance Registry System Guanidine (113-00-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H319-H410
Precautionary statements  P264-P273-P280-P337+P313-P391-P501
RIDADR  1759
HazardClass  8
PackingGroup  II
Hazardous Substances Data 113-00-8(Hazardous Substances Data)
Toxicity LD50 i.p. in mice: 350 mg/kg (Podlesnaya)

guanidine price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation NUC0000978 GUANIDINE 95.00% 113-00-8 5G $909.56 2021-12-16 Buy
American Custom Chemicals Corporation NUC0000978 GUANIDINE 95.00% 113-00-8 10G $1334.03 2021-12-16 Buy
Product number Packaging Price Buy
NUC0000978 5G $909.56 Buy
NUC0000978 10G $1334.03 Buy

guanidine Chemical Properties,Uses,Production

Chemical Properties

Colorless crystals. Soluble inwater and alcohol. Combustible. Guanidine is a strong monobasic Bronsted base, which absorbs water and carbon dioxide from the air and forms strongly alkaline solutions with water and alcohols; the pH of a 20 wt % aqueous solution is ca. 13.5 (25 ℃). In aqueous solution at elevated temperature guanidine is hydrolyzed to urea; airtight alcohol solutions are stable. Guanidine is infinitely soluble in water, ethanol, methanol, and dimethylformamide.

Uses

Organic synthesis

Uses

Guanidine is an intermediate in synthesizing N-Formylguanidine (F700505), which is used in the preparation of Amiloride (A578700), a sodium channel blocker used as a diuretic drug.

Production Methods

Guanidine is formed (1) by heating ammonium thiocyanate to 180 °C, (2) by ammonolysis of orthocarbonates, C(OC2H5)4 + 3NH3 → (NH2)2C=NH + 4C2H5OH, (3) by ammonolysis of chloropicrin, Cl3CNO2 + 7NH3 → NH2)2 C=NH + 3NH4Cl + N2 + 3H2O, (4) by ammonolysis of cyanogen chloride, ClCN + NH3 → ClC(NH2)=NH → HN=C=NH → (NH2)2 C=NH.
Guanidine forms salts with acids, e.g., guanidine nitrate, HNC(NH2)2 · HNO3. By heating at 120 °C for several hours, a mixture of ammonium thiocyanate and dicyanodiamide, guanidine thiocyanate solution is obtained by extracting with water. Treating guanidine with a mixture of nitric and sulfuric acids forms nitroguanidine which is reduced by zinc and acetic acid to aminoguanidine.
By treating aminoguanidine (1) with dilute acid or alkali, there is obtained, first, semicarbazide, finally hydrazine; (2) with nitrous acid, diazoguanidine which is decomposed by alkali into alkali azide (e.g., NaN3) plus cyanamide (H2N·CN) plus water.

Definition

ChEBI: Guanidine is an aminocarboxamidine, the parent compound of the guanidines. It is a one-carbon compound, a member of guanidines and a carboxamidine. It is a conjugate base of a guanidinium.

Agricultural Uses

Carbamidine is another name for guanidine. It is a crystalline basic compound related to urea. It forms a number of salts which are used as fertilizers. Guanidine phosphate is an example.

Purification Methods

Crystallise it from water/EtOH under nitrogen. It is very deliquescent and absorbs CO2 from the air readily. [Jones Trans Faraday Soc 55 524 1959, Beilstein 3 H 82, 3 I 39, 3 II 69, 3 III 154, 3 IV 148.]

Global( 65)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 FandaChem@Gmail.com China 9087 55
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22963 58
career henan chemical co
+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
AFINE CHEMICALS LIMITED
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Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9639 58
CD Chemical Group Limited
+8615986615575 info@codchem.com China 20342 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923 1026@dideu.com China 8670 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58

View Lastest Price from guanidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Guanidine pictures 2024-10-28 Guanidine
113-00-8
US $195.00-692.00 / mg 97% 10g TargetMol Chemicals Inc.
guanidine pictures 2019-12-27 guanidine
113-00-8
US $2.00 / KG 1KG ≥98% 20 tons Career Henan Chemical Co
  • Guanidine pictures
  • Guanidine
    113-00-8
  • US $195.00-692.00 / mg
  • 97%
  • TargetMol Chemicals Inc.
  • guanidine pictures
  • guanidine
    113-00-8
  • US $2.00 / KG
  • ≥98%
  • Career Henan Chemical Co
carbamamidine Diaminomethanimine Guanidinebase Ribavirin Impurity T Guanidine 98% Guanidine, free base tert-Butyl 3-[(4-chlorobenzyl)amino]propanoate Metformin Impurity 33 imidourea Carbamidine Metformin Impurity 33 Monomer 113-00-8 Pharmaceutical Intermediates