PROTAC PD-1/PD-L1 degrader-1
- CAS No.
- 2447066-37-5
- Chemical Name:
- PROTAC PD-1/PD-L1 degrader-1
- Synonyms
- PROTAC PD-1;PROTAC PD-1/PD-L1 degrader-1
- CBNumber:
- CB38964240
- Molecular Formula:
- C59H58ClN7O11
- Molecular Weight:
- 1076.6
- MDL Number:
- MOL File:
- 2447066-37-5.mol
PROTAC PD-1/PD-L1 degrader-1 Chemical Properties,Uses,Production
Biological Activity
PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 PROTAC based on Cereblon E3 ligand, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner[1]. PROTAC PD-1/PD-L1 degrader-1 (compound p22) reduces cell surface PD-L1 expression for more than 14%[1].PROTAC PD-1/PD-L1 degrader-1 (1-10 μM; 24 hours) reduces PD-L1 expression in a dose-dependent manner by 21% and 35% at 1 μM and 10 μM, respectively[1].
References
[1]. Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
PROTAC PD-1/PD-L1 degrader-1 Preparation Products And Raw materials
Raw materials
Preparation Products
PROTAC PD-1/PD-L1 degrader-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Novel Biomedical Co., Ltd. | 028-85255396 18302801538 | cdnovell@163.com | China | 2264 | 58 |
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1366 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4371 | 58 |
| Baoji Didu Pharmaceutical and Chemical Co., Ltd | 029-61856358 15829046862 | 1035@dideu.com | China | 10011 | 58 |