5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
- CAS No.
- 18059-99-9
- Chemical Name:
- 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
- Synonyms
- LM-2909;Deparon hydrochloride;demexiptiline hydrochloride;5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride
- CBNumber:
- CB3914472
- Molecular Formula:
- C18H19ClN2O
- Molecular Weight:
- 314.80926
- MDL Number:
- MOL File:
- 18059-99-9.mol
Melting point | 232-233° |
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FDA UNII | ULT22161QA |
SAFETY
Risk and Safety Statements
RIDADR | 3249 |
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HazardClass | 6.1(b) |
PackingGroup | III |
Toxicity | LD50 in rats (mg/kg): 330 orally, 25 i.v. (Rossi) |
5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Chemical Properties,Uses,Production
Originator
Deparon,Aron,France,1981
Uses
Demexiptiline Hydrochloride is a tricyclic antidepressant that can also serve as a new potential antibacterial agent.
Manufacturing Process
1.15 g of Na are dissolved in 100 ml of absolute ethanol; 10 g of 5-oximino5H-dibenzo[a,d]cycloheptene are introduced, followed by boiling under reflux for 1 hour and evaporation to dryness. The residue is dissolved in dimethylformamide and part of the solvent is distilled off. The solution is now cooled to about 20°C and there are added 5.3 g of methylaminoethyl chloride which is prepared below 10°C from the corresponding hydrochloride by supersaturation with potassium carbonate. The mixture is then heated to 100°C for 1? hours. Finally, the mixture is evaporated to dryness, the residue dissolved in ether/water and the ethereal phase washed with water. After drying of the ethereal phase with potassium carbonate, 8.5 g of the hydrochloride of 5-β-methylaminoethoxyimino-5H-dibenzo[a,d]cycloheptene (melting point 232°C to 233°C) are obtained.
Therapeutic Function
Antidepressant
5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Preparation Products And Raw materials
5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
Supplier | Advantage |
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Energy Chemical | 58 |