| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:DemexiptilineHydrochloride
CAS:18059-99-9
Purity:NULL Package:10mg;20mg;2mg;5mg Remarks:NULL
|
| Company Name: |
CLEARSYNTH LABS LTD.
|
| Tel: |
+91-22-45045900 |
| Email: |
sales@clearsynth.com |
| Products Intro: |
Product Name:Demexiptiline Hydrochloride
CAS:18059-99-9
|
|
| | 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Basic information |
| | 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Chemical Properties |
| RIDADR | 3249 | | HazardClass | 6.1(b) | | PackingGroup | III | | Toxicity | LD50 in rats (mg/kg): 330 orally, 25 i.v. (Rossi) |
| | 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Usage And Synthesis |
| Originator | Deparon,Aron,France,1981 | | Uses | Demexiptiline Hydrochloride is a tricyclic antidepressant that can also serve as a new potential antibacterial agent. | | Manufacturing Process | 1.15 g of Na are dissolved in 100 ml of absolute ethanol; 10 g of 5-oximino5H-dibenzo[a,d]cycloheptene are introduced, followed by boiling under reflux
for 1 hour and evaporation to dryness. The residue is dissolved in
dimethylformamide and part of the solvent is distilled off. The solution is now
cooled to about 20°C and there are added 5.3 g of methylaminoethyl chloride
which is prepared below 10°C from the corresponding hydrochloride by
supersaturation with potassium carbonate. The mixture is then heated to
100°C for 1? hours. Finally, the mixture is evaporated to dryness, the residue
dissolved in ether/water and the ethereal phase washed with water. After
drying of the ethereal phase with potassium carbonate, 8.5 g of the
hydrochloride of 5-β-methylaminoethoxyimino-5H-dibenzo[a,d]cycloheptene
(melting point 232°C to 233°C) are obtained. | | Therapeutic Function | Antidepressant |
| | 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(methylamino)ethyl]oxime monohydrochloride Preparation Products And Raw materials |
|