ChemicalBook >> CAS DataBase List >>colchiceine
colchiceine
- CAS No.
- 477-27-0
- Chemical Name:
- colchiceine
- Synonyms
- NSC 3341;NSC 33411;colchiceine;O10-Demethylcolchicine;Colchicine EP Impurity F;N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim;Colchicine Impurity 6（Colchicine EP Impurity F）;N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide;(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one;(S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
- CBNumber:
- CB3916380
- Molecular Formula:
- C21H23NO6
- Molecular Weight:
- 385.41
- MDL Number:
- MOL File:
- 477-27-0.mol
- MSDS File:
- SDS
Last updated:2023-05-15 10:43:57
| Melting point | 172-1740C |
|---|---|
| alpha | D25 -255.1° (c = 1 in chloroform) |
| Boiling point | 511.86°C (rough estimate) |
| Density | 1.2400 |
| refractive index | 1.5614 (estimate) |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 7.59±0.40(Predicted) |
| form | Solid |
| color | Off-White to Pale Yellow |
| EWG's Food Scores | 1 |
| FDA UNII | HJ30158L57 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS08,GHS05,GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300-H318-H330-H340 |
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P280-P305+P351+P338-P310 |
| Toxicity | LD50 intraperitoneal in mouse: 84mg/kg |
colchiceine price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C638500 | Colchiceine | 477-27-0 | 50mg | $320 | 2021-12-16 | Buy |
| Usbiological | 007021 | Colchiceine | 477-27-0 | 10mg | $460 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0000488 | COLCHICEINE 95.00% | 477-27-0 | 10MG | $721.88 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20539 | Colchiceine | 477-27-0 | 250mg | $1000 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FC20539 | Colchiceine | 477-27-0 | 500mg | $1500 | 2021-12-16 | Buy |
colchiceine Chemical Properties,Uses,Production
Description
Colchicine is obtained by extracting the seeds and/or corm of Colchicum autumnale Linn′e. Colchicine is a specific drug for the treatment of gouty arthritis. It is especially useful in acute attacks but also is used prophylactically in conjunction with other drugs, such as allopurinol or phenylbutazone. The drug is believed to act by disrupting microtubular assembly in inflammatory cells, thereby impairing both their locomotion and their membrane function, including phagocytosis and the release of inflammatory mediators. The alkaloid is extremely toxic and must be used with care. Gastrointestinal adverse effects include nausea, vomiting, and diarrhea. Blood disorders, including agranulocytosis and aplastic anemia, sometimes are seen after prolonged administration of this drug.
Chemical Properties
Off- White to Pale Yellow Solid
Uses
A metabolite of Colchicine
Definition
ChEBI: Colchiceine is a cyclic ketone.
Trade name
Colchicina (Smith Kline, Brazil), Colchicine (Various, USA), ColchicumDispert (Solvay, Poland), Colabid (Major, USA).
colchiceine Preparation Products And Raw materials
Raw materials
Preparation Products
colchiceine Suppliers
Global( 59)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32344 | 50 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9685 | 58 |
View Lastest Price from colchiceine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-08-06 | Colchiceine
477-27-0
|
US $0.00-0.00 / mg | 5mg | 98% | 1000MG | Wuhan ChemNorm Biotech Co.,Ltd. |
-
- Colchiceine
477-27-0
- US $0.00-0.00 / mg
- 98%
- Wuhan ChemNorm Biotech Co.,Ltd.
477-27-0(colchiceine)Related Search:
(S)-7-Acetylamino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
colchiceine
N-[(7S)-5,6,7,9-Tetrahydro-10-hydroxy-1,2,3,-trimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide
NSC 3341
O10-Demethylcolchicine
NSC 33411
Colchicine EP Impurity F
Colchicine Impurity 6（Colchicine EP Impurity F）
N-[(7S,12aRa)-10-Hydroxy-1,2,3-trim
Acetamide, N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
(S)-N-(10-hydroxy-1,2,3-trimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide
N-(10-Hydroxy-1,2,3-trimethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-yl)acetamide
477-27-0
Various Metabolites and Impurities
Intermediates & Fine Chemicals
Metabolites & Impurities
Pharmaceuticals