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ChemicalBook >> CAS DataBase List >>RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Structure
RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE structure
CAS No.
185246-32-6
Chemical Name:
RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE
Synonyms
Rp 8 Br PET cGMPS,Rp8BrPETcGMPS;Rp-8-bromo-PET-Cyclic GMPS sodium;Rp-8-bromo-PET-Cyclic GMPS (sodium salt);RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'...;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt;RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE;Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt;Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder;Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt
CBNumber:
CB3972375
Molecular Formula:
C18H14BrN5NaO6PS
Molecular Weight:
562.266
MDL Number:
MOL File:
185246-32-6.mol
MSDS File:
SDS
Last updated:2024-10-28 23:16:16
Request For Quotation

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Properties

Melting point 240-300 °C(lit.)
storage temp. -20°C
solubility H2O: soluble15mg/mL at ≤60°C
form powder
color white to beige
FDA UNII 9QQM5R5DWL

SAFETY

Risk and Safety Statements

Safety Statements  22-24/25
WGK Germany  3

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich B6684 Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt ≥98% (HPLC), powder 185246-32-6 1mg $333 2024-03-01 Buy
Sigma-Aldrich B6684 Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate sodium salt ≥98% (HPLC), powder 185246-32-6 5mg $1070 2024-03-01 Buy
Cayman Chemical 18823 Rp-8-bromo-PET-Cyclic GMPS (sodium salt) ≥99% 185246-32-6 1mg $267 2024-03-01 Buy
Cayman Chemical 18823 Rp-8-bromo-PET-Cyclic GMPS (sodium salt) ≥99% 185246-32-6 5mg $1063 2024-03-01 Buy
TRC R700933 Rp-8-Br-PET-cyclicGMPSSodiumSalt 185246-32-6 2.5μmol $265 2021-12-16 Buy
Product number Packaging Price Buy
B6684 1mg $333 Buy
B6684 5mg $1070 Buy
18823 1mg $267 Buy
18823 5mg $1063 Buy
R700933 2.5μmol $265 Buy

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Chemical Properties,Uses,Production

Description

Rp-8-bromo-PET-Cyclic GMPS (Rp-8-bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis = 35 and 30 nM). It less potently inhibits protein kinase A (Ki = 11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC50 = 25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki = 1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

Uses

Rp-8-Br-PET-cyclic GMPS Sodium Salt is a competitive inhibitor of cGMP-dependent protein kinase (cGKI).

Biochem/physiol Actions

Rp-8-Br-PET-cGMPS is metabolically stable, competitive inhibitor of cGMP-dependent protein kinase G. Inhibits both PKG I (Ki?=?30 nM) and PKG II and blocks cGMP-gated retinal type ion channels (IC50?=?25 micromoles).

storage

Store at -20°C

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51456 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44806 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8140 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Sigma-Aldrich 80
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
MedBioPharmaceutical Technology Inc 58
Changzhou Furuisi Biotechnology Co., Ltd 58

View Lastest Price from RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Rp-8-Br-PET-cGMPS pictures 2024-10-28 Rp-8-Br-PET-cGMPS
185246-32-6
 US $668.00-2650.00 / mg 10g TargetMol Chemicals Inc.
RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT HYDRATE Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3μ:5μ-cyclic monophosphorothioate hydrate sodium salt Rp-8-Br-PET-cGMPS hydrate, Rp-β-Phenyl-1,N2-etheno-8-bromoguanosine 3μ,5μ-cyclic monophosphorothioate hydrate sodium salt Rp-8-bromo-PET-Cyclic GMPS (sodium salt) Rp-8-Bromo-β-phenyl-1,N2-ethenoguanosine 3′,5′-cyclic monophosphorothioate Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt Rp-8-Bromo-beta-phenyl-1,N2-ethenoguanosine 3',5'-cyclic monophosphorothioate sodium salt >=98% (HPLC), powder Rp-8-bromo-PET-Cyclic GMPS sodium Rp 8 Br PET cGMPS,Rp8BrPETcGMPS RP-8-BROMO-BETA-PHENYL-1,N2-ETHENOGUANOSINE 3',5'... 185246-32-6 C18H14N5O6PSBrNa C18H16BrN5NaO6PS