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Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)-

Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- structure

CAS No.: 1919828-81-1

Chemical Name:: Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)-

Synonyms: DDX3-IN-2;Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)-

CBNumber:: CB39819776

Molecular Formula:: C20H23N5O

Molecular Weight:: 349.43

MDL Number:

MOL File:: 1919828-81-1.mol

Last updated:2024-07-02 08:55:07

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Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Properties

Density	1.18±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	13.83±0.70(Predicted)
color	Off-white to gray

Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Chemical Properties,Uses,Production

Biological Activity

DDX3-IN-2 is an active DEADbox polypeptide 3 (DDX3) inhibitor with an IC50 value of 0.3 μM. DDX3-IN-2 shows a broad spectrum of antiviral activity. DDX3-IN-2 has the potential to overcome HIV resistance[1]. DDX3-IN-2 behaves as a competitive inhibitor with respect to the RNA substrate, which can be seen by the decrease in its inhibition potency as a function of increasing RNA substrate concentrations. DDX3-IN-2 is found to be completely inactive against the ATPase of DDX3, DDX1 helicase, and DENV NS3 helicase[1]. DDX3-IN-2 (20 mg/kg; tail vein injection) possesses excellent biocompatibility, and Wistar rats shows a good tolerance to the dose of 20 mg/kg[1].DDX3-IN-2 (10 mg/kg; i.v. bolus injection; 0~25 hours) rapidly eliminates the half-life elimination and the plasmatic clearance values[1].

References

[1]. Brai A, et al. Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Proc Natl Acad Sci U S A. 2016;113(19):5388-5393.

Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	23963	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	021-59167510 18117107507	vip@med-life.cn	China	5012	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9274	58

Supplier	Advantage
Aladdin Scientific	58
TargetMol Chemicals Inc.	58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd	58
RD International Technology Co., Limited	58

Urea, N-[4-(4-butyl-1H-1,2,3-triazol-1-yl)phenyl]-N'-(2-methylphenyl)- DDX3-IN-2 1919828-81-1