Esculentoside A
- CAS No.
- 65497-07-6
- Chemical Name:
- Esculentoside A
- Synonyms
- Esculentoside;ESCULENTOSIDE A;Esculentoside A-RM;Phytolaccasaponin E;Esculentoside A USP/EP/BP;Phytolaccasaponin E in methanol;Esculentoside A, 98%, from Phytolacca acinosa Roxb.;(2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester;Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2β,3β,4α,20β)-;(2S,4aR,6aS,6bR,8aR,9R,10R,11S,12aR,12bR,14bS)-10-(((2S,3R,4R,5R)-3,4-Dihydroxy-5-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-11-hydroxy-9-(hydroxymethyl)-2-(methoxycarbonyl)-2,6a,6b,9,12
- CBNumber:
- CB3983421
- Molecular Formula:
- C42H66O16
- Molecular Weight:
- 826.96
- MDL Number:
- MFCD30488995
- MOL File:
- 65497-07-6.mol
| Melting point | >192°C (dec.) |
|---|---|
| Boiling point | 936.7±65.0 °C(Predicted) |
| Density | 1.42±0.1 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.39±0.70(Predicted) |
| form | Solid |
| color | Pale Yellow |
| Stability | Hygroscopic |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Safety Statements | 24/25 |
| HS Code | 29389090 |
Esculentoside A price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 296973 | Esculentoside A | 65497-07-6 | 10mg | $470 | 2021-12-16 | Buy |
| Usbiological | 300241 | Esculentoside A | 65497-07-6 | 20mg | $390 | 2021-12-16 | Buy |
| TRC | E658875 | EsculentosideA | 65497-07-6 | 100mg | $720 | 2021-12-16 | Buy |
| Biosynth Carbosynth | OE33280 | Esculentoside A | 65497-07-6 | 50mg | $450 | 2021-12-16 | Buy |
| Biosynth Carbosynth | OE33280 | Esculentoside A | 65497-07-6 | 100mg | $700 | 2021-12-16 | Buy |
Esculentoside A Chemical Properties,Uses,Production
Uses
Esculentoside A is a saponin isolated from the root of Phytolacca esculenta. Modulates the immune response. and effects cell proliferation and apoptosis in cells. Anti-inflammatory. 500
Pharmacokinetics
Esculentoside A is a triterpenoid saponin isolated from the root of Phytolacca esculenta. Studies have revealed that this triterpenoid exhibits a strong anti-inflammatory property. Ci et al. (2015) observed the anti-inflammatory potency of esculentoside A against allergic airway inflammation in a mouse model. They found that the drug enhanced nuclear Nrf-2 translocation in the lungs of ovalbumin-challenged mice and also decreased airway inflammation (Ci et al., 2015). Esculentoside A enhanced the intracellular anti-oxidant potentials, reduced Th2 cytokine level and down-regulated the expression of adhesion molecule mRNA in lung tissues. Zhang et al. (2014) found that esculentoside A could rectify carbon tetrachlorideinduced acute liver injury in mice. The drug successfully cured the histopathological damage induced by carbon tetrachloride. Rectification has been also noted through the down-regulation of inflammatory molecules and oxidative stresses associated with PPAR-γ, NF-κB and ERK signal pathways (Zhang et al., 2014). Ma et al. (2013) analyzed the role of esculentoside A on lupus nephritis-induced BXSB mice (where male SB/Le mice and female C57BL/6 mice were hybridized, creating a recombinant inbred species). They observed that esculentoside A application significantly reduced urine protein excretion and improved renal function by promoting apoptosis of glomerular intrinsic cells and renal tubular epithelial cells (Ma et al., 2013). The efficacy was also aided by the down-regulation of inflammatory cytokines.
Wang et al. (2016) elucidated the role of esculentoside A against acetaminophen-induced liver toxicity in mice and observed that Nrf2-regulated the survival mechanism via the AMPK/ Akt/GSK3β pathway.
Esculentoside A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3772 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
View Lastest Price from Esculentoside A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Esculentoside A
65497-07-6
|
US $38.00-128.00 / mg | 99.81% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Esculentoside A
65497-07-6
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-06 | Esculentoside A
65497-07-6
|
US $1.00 / kg | 1 mg | 99% | 100KG | Career Henan Chemical Co |
-
- Esculentoside A
65497-07-6
- US $38.00-128.00 / mg
- 99.81%
- TargetMol Chemicals Inc.
-
- Esculentoside A
65497-07-6
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Esculentoside A
65497-07-6
- US $1.00 / kg
- 99%
- Career Henan Chemical Co