에스쿨렌토사이드A

에스쿨렌토사이드A
에스쿨렌토사이드A 구조식 이미지
카스 번호:
65497-07-6
한글명:
에스쿨렌토사이드A
동의어(한글):
에스쿨렌토사이드A
상품명:
Esculentoside A
동의어(영문):
Esculentoside;ESCULENTOSIDE A;Phytolaccasaponin E;Esculentoside A USP/EP/BP;Esculentoside A, 98%, from Phytolacca acinosa Roxb.;Olean-12-ene-28,29-dioic acid, 3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-, 29-methyl ester, (2β,3β,4α,20β)-;(2b,3b,4a,20b)-3-((4-O-beta-D-Glucopyranosyl-beta-D-xylopyranosyl)oxy)-2,23-dihydroxyolean-12-ene-28,29-dioic acid 29-methyl ester
CBNumber:
CB3983421
분자식:
C42H66O16
포뮬러 무게:
826.96
MOL 파일:
65497-07-6.mol
MSDS 파일:
SDS

에스쿨렌토사이드A 속성

녹는점
>192°C (dec.)
끓는 점
936.7±65.0 °C(Predicted)
밀도
1.42±0.1 g/cm3(Predicted)
저장 조건
Hygroscopic, -20°C Freezer, Under inert atmosphere
용해도
DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)
4.39±0.70(Predicted)
물리적 상태
고체
물리적 상태
단단한 모양
색상
옅은 노랑
안정성
흡습성
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
안전지침서 24/25
HS 번호 29389090
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 GHS hazard pictograms P264, P270, P301+P312, P330, P501
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P301+P312 삼켜서 불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P330 입을 씻어내시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

에스쿨렌토사이드A C화학적 특성, 용도, 생산

용도

Esculentoside A is a saponin isolated from the root of Phytolacca esculenta. Modulates the immune response. and effects cell proliferation and apoptosis in cells. Anti-inflammatory. 500

Pharmacokinetics

Esculentoside A is a triterpenoid saponin isolated from the root of Phytolacca esculenta. Studies have revealed that this triterpenoid exhibits a strong anti-inflammatory property. Ci et al. (2015) observed the anti-inflammatory potency of esculentoside A against allergic airway inflammation in a mouse model. They found that the drug enhanced nuclear Nrf-2 translocation in the lungs of ovalbumin-challenged mice and also decreased airway inflammation (Ci et al., 2015). Esculentoside A enhanced the intracellular anti-oxidant potentials, reduced Th2 cytokine level and down-regulated the expression of adhesion molecule mRNA in lung tissues. Zhang et al. (2014) found that esculentoside A could rectify carbon tetrachlorideinduced acute liver injury in mice. The drug successfully cured the histopathological damage induced by carbon tetrachloride. Rectification has been also noted through the down-regulation of inflammatory molecules and oxidative stresses associated with PPAR-γ, NF-κB and ERK signal pathways (Zhang et al., 2014). Ma et al. (2013) analyzed the role of esculentoside A on lupus nephritis-induced BXSB mice (where male SB/Le mice and female C57BL/6 mice were hybridized, creating a recombinant inbred species). They observed that esculentoside A application significantly reduced urine protein excretion and improved renal function by promoting apoptosis of glomerular intrinsic cells and renal tubular epithelial cells (Ma et al., 2013). The efficacy was also aided by the down-regulation of inflammatory cytokines.
Wang et al. (2016) elucidated the role of esculentoside A against acetaminophen-induced liver toxicity in mice and observed that Nrf2-regulated the survival mechanism via the AMPK/ Akt/GSK3β pathway.

에스쿨렌토사이드A 준비 용품 및 원자재

원자재

준비 용품


에스쿨렌토사이드A 공급 업체

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