ChemicalBook >> CAS DataBase List >>Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester
![Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Structure](CAS/20211123/GIF/2377474-67-2.gif)
- CAS No.
- 2377474-67-2
- Chemical Name:
- Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester
- Synonyms
- Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester;Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester;Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1′-[dithiobis(2,1-ethanediyl-1,4-pip eridinediyl-2,1-ethanediyl)] ester(SSPalmO-Phe)
- CBNumber:
- CB410557907
- Molecular Formula:
- C70H112N2O8S2
- Molecular Weight:
- 1173.79
- MDL Number:
- MOL File:
- 2377474-67-2.mol
Last updated:2024-07-02 08:55:07
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Properties
| Boiling point | 1028.5±65.0 °C(Predicted) |
|---|---|
| Density | 1.038±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Ethanol: soluble |
| pka | 8.85±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Chemical Properties,Uses,Production
Biological Activity
SSPalmO-Phe is an ionizable cationic self-degradable disulfide-cleavable (SS-cleavable) proton-activated lipid-like material (SSPalm; pKa = 5.97 in a TNS binding assay).1,2 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, and antisense oligonucleotides (ASOs). Intravenous administration of mouse erythropoietin (EPO) mRNA in SSPalmO-Phe-containing LNPs increases serum EPO levels in mice.1
References
1.Tanaka, H., Takahashi, T., Konishi, M., et al.Self-degradable lipid-like materials based on "hydrolysis accelerated by the intra-particle enrichment of reactant (HyPER)" for messenger RNA deliveryAdv. Funct. Mater.301910575(2020) 2.Tanaka, H., Takata, N., Sakurai, Y., et al.Delivery of oligonucleotides using a self-degradable lipid-like materialPharmaceutics13(4)544(2021)
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Preparation Products And Raw materials
Raw materials
Preparation Products
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester Suppliers
Global( 10)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Send Pharmaceutical Technology Co., Ltd. | 021-58088081 Q2816483246 | hailey@shsendpharm.com | China | 3137 | 55 |
| Shanghai Changyu Medical Technology Co. Ltd. | +86-13301875428 | sales@changyuhe.com | China | 297 | 58 |
| Shochem(Shanghai)Co.,Ltd | +86-021-51783479 +86-13816874662 | info@shochem.com | China | 301 | 58 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| Guangzhou Weihua Biotechnology Co., Ltd | 020-020-37239396 18922492046 | weihuasw@foxmail.com | China | 2074 | 58 |
| Shanghai Easy CDMO Co.,Ltd | 021-61734564 | August@easycdmo.com | China | 10010 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Shochem (Shanghai) Co.,Ltd | 13611745246 13816874662 | sales@shochem.com | China | 447 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 40857 | 58 |
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1'-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester
Benzeneacetic acid, 4-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]-, 1,1′-[dithiobis(2,1-ethanediyl-1,4-pip eridinediyl-2,1-ethanediyl)] ester(SSPalmO-Phe)
2377474-67-2
C70H112N2O8S2
LNP