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NEUROPEPTIDE S (HUMAN)

CAS No.
412938-67-1
Chemical Name:
NEUROPEPTIDE S (HUMAN)
Synonyms
NPS (HUMAN);SFRNGVGTGMKKTSFQRAKS;NEUROPEPTIDE S (HUMAN);Neuropeptide S, NPS, human;Neuropeptide S (huMan) NPS (huMan);SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER;H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH;REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH;L-Serine, L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-
CBNumber:
CB4106928
Molecular Formula:
C93H155N31O28S
Molecular Weight:
2187.48
MDL Number:
MFCD07368606
MOL File:
412938-67-1.mol
Last updated:2024-07-02 08:55:07

NEUROPEPTIDE S (HUMAN) Properties

Density 1.49±0.1 g/cm3(Predicted)
form Solid
color White to off-white

NEUROPEPTIDE S (HUMAN) price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J66262 Neuropeptide S, human 412938-67-1 0.2mg $111 2021-12-16 Buy
Alfa Aesar J66262 Neuropeptide S, human 412938-67-1 0.5mg $201 2021-12-16 Buy
Alfa Aesar J66262 Neuropeptide S, human 412938-67-1 1mg $301 2021-12-16 Buy
Usbiological 302078 Neuropeptide S, Human 412938-67-1 100ug $372 2021-12-16 Buy
American Custom Chemicals Corporation PEP0003707 NEUROPEPTIDE S, HUMAN 95.00% 412938-67-1 0.5MG $676.83 2021-12-16 Buy
Product number Packaging Price Buy
J66262 0.2mg $111 Buy
J66262 0.5mg $201 Buy
J66262 1mg $301 Buy
302078 100ug $372 Buy
PEP0003707 0.5MG $676.83 Buy

NEUROPEPTIDE S (HUMAN) Chemical Properties,Uses,Production

Biological Activity

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50=9.4 nM). It (TFA) increases motor activity and wakefulness in mice, and has potential for Alzheimer's disease (AD) research.

in vitro

Neuropeptide S human (4 pM to 1.7 nM; 48 hours) retains full agonist activity with an EC 50 of 6.7 ± 2.4 nM, the binding of [ 125I ] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (K d = 0.33 ± 0.12 nM). Neuropeptide S human (1 pM-3 μM; 48 hours) are used to compete with 0.15 nM [ 125I I] Y10-NPS, [ 125I I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC 50 = 0.42 ± 0.12 nM).

in vivo

Neuropeptide S human (0.1 nM-1 nM; icv) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice .

Animal Model: Male C57Bl/6 mice
Dosage: 0.1 nM, 1 nM
Administration: Intracerebroventricular (icv) injection
Result: Increased locomotor activity and promoted wakefulness.

target

EC50: 9.4 nM (neuropeptide S receptor)

NEUROPEPTIDE S (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

NEUROPEPTIDE S (HUMAN) Suppliers

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SFRNGVGTGMKKTSFQRAKS SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER NPS (HUMAN) NEUROPEPTIDE S (HUMAN) H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH Neuropeptide S, NPS, human Neuropeptide S (huMan) NPS (huMan) L-Serine, L-seryl-L-phenylalanyl-L-arginyl-L-asparaginylglycyl-L-valylglycyl-L-threonylglycyl-L-methionyl-L-lysyl-L-lysyl-L-threonyl-L-seryl-L-phenylalanyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl- 412938-67-1 Various peptides peptide