Zopolrestat
- CAS No.
- 110703-94-1
- Chemical Name:
- Zopolrestat
- Synonyms
- Xedia;Alond;CP-73850;Zopalrestat;Zopolrestatum;Zopolrestat, CP-73850;Zopolrestat >=98% (HPLC);BCSVCWVQNOXFGL-UHFFFAOYSA-N;3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid;3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid
- CBNumber:
- CB41180112
- Molecular Formula:
- C19H12F3N3O3S
- Molecular Weight:
- 419.38
- MDL Number:
- MFCD00865476
- MOL File:
- 110703-94-1.mol
- MSDS File:
- SDS
| Melting point | 197-198℃ |
|---|---|
| Density | 1.58 |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | pKa (dioxane/water): 5.46 (1:1); 6.38 (2:1) |
| color | off-white to light brown |
| FDA UNII | 1PV3S9WP3D |
Zopolrestat price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Z4527 | Zopolrestat ≥98% (HPLC) | 110703-94-1 | 10mg | $122 | 2024-03-01 | Buy |
| Sigma-Aldrich | Z4527 | Zopolrestat ≥98% (HPLC) | 110703-94-1 | 50mg | $475 | 2024-03-01 | Buy |
| Cayman Chemical | 29185 | Zopolrestat | 110703-94-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29185 | Zopolrestat | 110703-94-1 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29185 | Zopolrestat | 110703-94-1 | 10mg | $214 | 2024-03-01 | Buy |
Zopolrestat Chemical Properties,Uses,Production
Originator
Alond,Pfizer
Uses
Antidiabetic; inhibitor (aldose reductase).
Manufacturing Process
A mixture of 2-methyl-5-trifluoromethylbenzothiazole (1 mole-equivalent), N- bromosuccinimide (1 mole-equivalent), carbon tetrachloride (700 ml) and a catalytic amount of benzoyl peroxide (0.2 g) was refluxed under irradiation by an UV lamp for 14 hours. The reaction mixture was cooled to room temperature, filtered to remove the precipitated succinimide and the filtrate was evaporated to dryness. The resulting solid was chromatographed over silica gel to obtain the 2-bromomethyl-5-trifluoromethyl-benzothiazole. To a mixture of ethyl 4-oxo-3H-phthalazin-1-ylacetate (1 mole-equivalent) and sodium hydride (50% w/w dispersion in mineral oil) in dimethylformamide (150 ml) was added 2-bromomethyl-5-trifluoromethylbenzothiazole (1 mole- equivalent) and the resulting mixture stirred at room temperature for 1 hour. This reaction mixture was poured over ice-water (500 ml); sufficient 10% HCl was added to adjust the pH to about 4.0 and the precipitated crude solid was collected. This was chromatographed over silica gel to obtain the ethyl[4-oxo- 3-(5-trifluoromethylbenzothiazol-2-yl)-3,4-dihydro-phthalazin-1-yl]acetate; MP: 134°-136°C. A solution of methyl or ethyl [4-oxo-3-(5-trifluoromethylbenzothiazol-2-yl)- 3,4-dihydrophthalazin-1-yl]acetate (1 mole-equivalent) in methanol (50 ml)
Therapeutic Function
Aldose reductase inhibitor
Zopolrestat Preparation Products And Raw materials
Raw materials
Preparation Products
Zopolrestat Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9815 | 79 |
| Shanghai Hekang Biotechnology Co., Ltd. | 18939837085 | youchemicals@gmail.com | China | 1830 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
View Lastest Price from Zopolrestat manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Zopolrestat
110703-94-1
|
US $30.00-64.00 / mg | 98.09% | 10g | TargetMol Chemicals Inc. |
-
- Zopolrestat
110703-94-1
- US $30.00-64.00 / mg
- 98.09%
- TargetMol Chemicals Inc.
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