3,3'-DIETHYLTHIADICARBOCYANINE IODIDE

Description

Dithiazanine iodide is a green, needle-likecrystalline solid which decomposes at 248℃. Sulfur-likeodor. Molecular weight= 519.51. Melting point 5 225℃;Hazard Identification (based on NFPA-704 M RatingSystem): Health 3, Flammability 0, Reactivity 1. Insolublein water.

Chemical Properties

green crystalline powder

Originator

Delvex,Lilly,US,1958

Uses

It is employed as a solvent soluble laser dye. DTDCi is used as fluorescent contrast agent in three-dimensional fluorescence lifetime tomography and as a dye for rapid genetic screening. It is a potential sensitive probe useful for fluorometric analysis of transferable membrane pores and effects of membrane potential on Na cotransports in eel intestinal brush-border membrane vesicles.

Uses

Sensitizer for photographic emulsions.

Uses

DTDCi is used as;

• Fluorescent contrast agent in three-dimensional fluorescence lifetime tomography.
• Dye for rapid genetic screening.

Manufacturing Process

3.05 g of 1-methylbenzthiazole ethiodide, 1.11 g of β-ethyl thio acrolein diethyl acetal and 15 cc of pyridine were mixed and boiled gently under reflux for 15 minutes. The reaction mixture was then poured into an aqueous solution of potassium iodide. The dye was precipitated and was filtered off, and washed with ethyl alcohol and ether. Recrystallization from methyl alcohol solution yielded the dye as green needles. Melting point 248°C with decomposition.

brand name

Abminthic;Anguifugan;D.i.m.;Deselmine;Dilombrine;Dithiazine (dye);Dizan;Eastman 7663;Elmizin;Nekel;Omni-passin;Ossiurene;Telmicid;Telmide.

Therapeutic Function

Anthelmintic

World Health Organization (WHO)

Dithiazanine iodide, an anthelminthic, was introduced in 1959 for the treatment of strongyloid worms and whipworms. Between 1961 and 1964 its use was associated with eight fatal cases of severe acidosis and shock. Although the drug is not significantly absorbed from the gut, in normal circumstances it was assumed that these fatalities were due to atypically high uptake from inflamed intestinal mucosa. Dithiazanine iodide has been superseded by safer and more effective drugs; however, it may remain available in some countries.

General Description

Green, needle-like crystals. Used as a veterinary anthelmintic, as a sensitizer for photographic emulsions and as an insecticides. Not registered as a pesticide in the U.S.

Reactivity Profile

An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

Highly toxic by mouth. (Non-Specific -- Pesticide, Solid, n.o.s.) Poisonous if swallowed, or if dust is inhaled.

Fire Hazard

When heated to decomposition, 3,3'-DIETHYLTHIADICARBOCYANINE IODIDE emits toxic fumes of iodine, sulfur oxides, and nitrogen oxides.

Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. When heated to decomposition it emits very toxic fumes of I-, SOx, and NOx. See also IODIDES.

Potential Exposure

This material is used as a plasticizer,as a rubber accelerator; and as an intermediate inmanufacturing of pesticides

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area.

Shipping

Pesticides, solid, toxic, n.o.s. have a labelrequirement of “POISONOUS/TOXIC MATERIALS.”They fall in Hazard Class 6.1 and this material in PackingGroup II.

Incompatibilities

Stable under normal conditions of temperature and pressure. Keep away from alkalies, strongoxidizers.