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pristimerin

pristimerin structure

CAS No.: 1258-84-0

Chemical Name:: pristimerin

Synonyms: pristimerin;Pristimerine;Pristimerin-RM;Celastrol-methylether;Pristimerin(NSC 99281);Celastrol methyl ester;Pristimerin - CAS 1258-84-0 - Calbiochem;3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester;3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester;(9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester

CBNumber:: CB41360260

Molecular Formula:: C30H40O4

Molecular Weight:: 464.64

MDL Number:: MFCD01711331

MOL File:: 1258-84-0.mol

Last updated:2024-11-19 23:02:33

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pristimerin Properties

Melting point	219.5°C
Boiling point	488.1°C (rough estimate)
Density	1.0271 (rough estimate)
refractive index	1.4800 (estimate)
storage temp.	-20°C
solubility	DMSO: ≥5mg/mL
form	Red solid
pka	8.60±0.70(Predicted)
color	orange
FDA UNII	28ZK7PR57S

SAFETY

Risk and Safety Statements

Toxicity	LD50 oral in mouse: 8gm/kg

pristimerin price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P0020	Pristimerin ≥98% (HPLC)	1258-84-0	5mg	$240	2024-03-01	Buy
Sigma-Aldrich	530070	Pristimerin	1258-84-0	5mg	$172	2024-03-01	Buy
Cayman Chemical	13621	Pristimerin ≥98%	1258-84-0	5mg	$97	2024-03-01	Buy
Cayman Chemical	13621	Pristimerin ≥98%	1258-84-0	10mg	$184	2024-03-01	Buy
Sigma-Aldrich	PHL83303	Pristimerin phyproof? Reference Substance	1258-84-0	10mg	$514	2024-03-01	Buy

Product number	Packaging	Price	Buy
P0020	5mg	$240	Buy
530070	5mg	$172	Buy
13621	5mg	$97	Buy
13621	10mg	$184	Buy
PHL83303	10mg	$514	Buy

pristimerin Chemical Properties,Uses,Production

Description

Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate cannabinoid receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC₅₀ = 93 nM). Its actions are rapid, reversible, and noncompetitive. Pristimerin (1 μM) significantly increases 2-AG levels in isolated rat neurons, indicating that it inhibits endogenous MAGL in cultured cells. Moreover, it does not increase levels of palmitoyl ethanolamide, suggesting that pristimerin does not affect the activity of fatty acid amide hydrolase (FAAH).

Uses

antineoplastic, antiinflammatory

Uses

Pristimerin is a triterpenoid that inhibits tumor angiogenesis by targeting VEGFR2 activation and is known to exhibit anti-inflammatory properties.

Definition

ChEBI: Pristimerin is a carboxylic ester.

General Description

A cell-permeable plant dienone-phenolic triterpenoid, naturally isolated from tripterygium wilfordii, whose inhibitory activities against proteasome chymotrypsin subunit (IC₅₀ = 2.2 and 3.0 μM against purified rabbit 20S and human 26S proteasome, respectively) and cellular NF-κB pathway/IKK activation most likely account for its reported anticancer efficacy both in vitro (IC₅₀ ≤610 nM in A549, K562, KBM5, MCF-7, MDA-MB-231, HepG2, and primary human leukemia cell cultures) and in mice in vivo (1 to 2.5 mg/kg/day, s.c.), including imatinib/STI571-resistant cancer cells harboring Bcr-Abl T315I mutation. Also reported to inhibit the activity of monoacylglycerol lipase (MGL), the enzyme that hydrolyzes and deactivates the cannabionoid receptor ligand 2-Arachidonoyl-sn-glycerol (2-AG), in a reversible manner with high potency (IC₅₀ = 93 nM).

Biological Activity

Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC 50 = 93 nM). Also suppresses NF- κ B activation via inhibition of proteasome chymotrypsin-like activity and IKK α / β . Displays antitumor, anti-inflammatory and antimicrobial activities.

pristimerin Preparation Products And Raw materials

Raw materials

Preparation Products

pristimerin Suppliers

Global( 171)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-15536356810	1022@dideu.com	China	3882	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5857	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3619	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3772	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shanghai Standard Technology Co., Ltd.	18502101150	ft-sales@nature-standard.com	CHINA	1923	58

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Chongqing Chemdad Co., Ltd	58
Shanghai Standard Technology Co., Ltd.	58

View Lastest Price from pristimerin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Pristimerin 1258-84-0	US $33.00-129.00 / mg		99.59%	10g	TargetMol Chemicals Inc.
2024-10-25	Pristimerin 1258-84-0	US $40.00 / kg	1kg	0.99	10 tons	Hebei Yanxi Chemical Co., Ltd.
2024-08-11	Pristimerin 1258-84-0	US $0.00-0.00 / KG	1KG	99.0%	10000KG	Shaanxi Dideu Medichem Co. Ltd

Pristimerin
1258-84-0
US $33.00-129.00 / mg
99.59%
TargetMol Chemicals Inc.

Pristimerin
1258-84-0
US $40.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

Pristimerin
1258-84-0
US $0.00-0.00 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

pristimerin Spectrum

pristimerin(1258-84-0)¹HNMR

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alpha-Terpinene pristimerin 2,2,4,4,5,5,7,7-OCTAMETHYLOCTANE

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pristimerin 3-Hydroxy-2-oxo-24-nor-D:A-friedoolean-1(10),3,5,7-tetren-29-oic acid methyl ester Celastrol-methylether (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oicacidmethylester (9b,13a,14b,20a)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tertraen-29-oic acid methyl ester 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester Celastrol methyl ester Pristimerin(NSC 99281) Pristimerine Pristimerin - CAS 1258-84-0 - Calbiochem 24,25,26-Trinoroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-9,13-dimethyl-2-oxo-, methyl ester, (9β,13α,14β,20α)- Methyl (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate Pristimerin-RM 1258-84-0 C30H40O4