Celastrol
- CAS No.
- 34157-83-0
- Chemical Name:
- Celastrol
- Synonyms
- Tripterine;Celastro;TRIPTERIN;NSC70931;Celatrol;CELASTROL;Celasterol;CELASTROL(SH);Celastrol >Celastrol ,98%
- CBNumber:
- CB7146431
- Molecular Formula:
- C29H38O4
- Molecular Weight:
- 450.61
- MDL Number:
- MFCD03424073
- MOL File:
- 34157-83-0.mol
- MSDS File:
- SDS
Melting point | 219-230°C |
---|---|
Boiling point | 645.7±55.0 °C(Predicted) |
Density | 1.2 |
storage temp. | -20°C |
solubility | DMSO: >10mg/mL |
pka | 4.78±0.70(Predicted) |
form | solid |
color | red |
λmax | 424nm(MeOH)(lit.) |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
LogP | 7.080 (est) |
CAS DataBase Reference | 34157-83-0(CAS DataBase Reference) |
FDA UNII | L8GG98663L |
Celastrol price More Price(56)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | C0869 | Celastrol ≥98% (HPLC), solid | 34157-83-0 | 10mg | $220 | 2024-03-01 | Buy |
Sigma-Aldrich | 219465 | Celastrol | 34157-83-0 | 10mg | $245 | 2024-03-01 | Buy |
TCI Chemical | C2737 | Celastrol >98.0%(HPLC) | 34157-83-0 | 25mg | $276 | 2024-03-01 | Buy |
Cayman Chemical | 70950 | Celastrol ≥98% | 34157-83-0 | 5mg | $76 | 2024-03-01 | Buy |
Cayman Chemical | 70950 | Celastrol ≥98% | 34157-83-0 | 10mg | $142 | 2024-03-01 | Buy |
Celastrol Chemical Properties,Uses,Production
Pharmacological effects
- Tripterine is a natural product with a variety of biological activity. It has a strong antioxidant effect, anti-cancer neovascularization effect as well as anti-rheumatoid effect. It is mainly isolated from the root bark of the celastraceae plant, Tripterygium wilfordii. It is one of the active ingredients contained in the rheumatoid-treatment drug Tripterygium tablet, Tripterygium Glycosides tablets and other preparations.
- The major activity and pharmacological effects of Tripterine:
- Cytotoxic activity. In vitro, it has non-specific cytotoxic activity against P388 and a group of human cancer cell lines.
- Immune regulation. It could significantly inhibit the formation of hemolytic plaque cells in mouse spleen cells and significantly inhibit the mice delayed-type hypersensitivity.
- Anti-inflammatory effect. At a dose of 0.5mg/kg, it could result in significant inhibition of the formation of rat cotton granuloma. At a dose of 0.1~1.0μg/mL, it could suppress the production of PGE2 induced by the yeast sugar; at a dose of 1.0μg/mL, it can inhibit the macrophage phagocytosis.
- The anti-oxidation effect of tripterine is 15 times that of tocopherol with an IC50 of 7μM. Inhibit the peroxidation occurring inside and outside of the mitochondrial membrane, direct removing the free radicals.
- Tripterine can extend the sleep time of mice triggered by the pentobarbital sodium.
- Immunosuppressive effect: inhibit the spleen cell proliferation of mice induced by PHA, ConA and LPS, further inhibiting the lymphocyte proliferation.
- It can inhibit the in vitro sperm fertilization capacity of guinea pig with the activity being significantly stronger than acetic acid gossypol.
- Anti-arthritic effect, it will inhibit the activity of interleukin-1 of inside and outside the mouse intraperitoneal macrophages, inhibit the production of interleukin-2 by mouse spleen cells and lower the level of PGE2 produced by rabbit synovial cells.
Application
Celastrol is an effective proteasome inhibitor. It has been confirmed that it is capable of inducing apoptosis of cancer cells through inhibiting proteasome activity.
Description
Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM). ?It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin activity (IC50=2.5 mM). Induces autophagy by targeting AR/miR-101 in prostate cancer cells.4 Induces UPR-dependent cell death in cancer cells.5 Cell permeable.
Chemical Properties
Orange Red Solid
Uses
Celastrol is an antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies. Celastrol also has been shown to have the power to kill tumor cells and can work as an anticarcinogen. It is also a leptin sensitizer with the potential to reduce weight in obesity.
Uses
antineoplastic, NO synthesis inhibitor, chaperone stimulant
Uses
Celastrol can be used as an antioxidant onstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies.
Uses
An antioxidant natural product Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be
Definition
ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).
Biochem/physiol Actions
Celastrol is a potent antioxidant, and anti-inflammatory agent. It is a novel HSP90 inhibitor (disrupts Hsp90/Cdc37 complex), that exhibits anticancer (anti-angiogenic - suppresses VEGFR expression); antioxidant (inhibits lipid peroxidation) and anti-inflammatory activity (suppresses iNOS and inflammatory cytokine production).
storage
+4°C
References
1) Sethi et al. (2007), Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κC-regulated gene products and TAK1-mediated NF-κB activation; Blood, 109 2727 2) Westerheide et al. (2004), Celastrols as inducers of the heat shock response and cytoprotection; J. Biol. Chem., 279 56053 3) Yang et al. (2006), Celastrol, a triterpene extracted from the Chinese “Thunder of God Vine” is a potent proteasome inhibitor and suppresses human prostate cancer cell growth in nude mice; Cancer Res., 66 4758 4) Guo et al. (2015), Celastrol Induces Autophagy by targeting AR/miR-101 in Prostate Cancer Cells; PLoS One, 10(10) e0140745 5) Fribley et al. (2015), Celastrol induces unfolded protein response-dependent cell death in head and neck cancer; Exp. Cell Res., 330 412
Celastrol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3921 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 301 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20294 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 873 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
View Lastest Price from Celastrol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-24 | Celastrol
34157-83-0
|
US $999.00-666.00 / g | 1g | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
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2024-08-23 | Celastrol; Bitter melon extract
34157-83-0
|
US $0.00-0.00 / kg | 1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
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2024-08-23 | Celastrol; Common Threewingnut root extract
34157-83-0
|
US $0.00-0.00 / kg | 1kg | ≥98% HPLC | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. |
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- Celastrol
34157-83-0
- US $999.00-666.00 / g
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Celastrol; Bitter melon extract
34157-83-0
- US $0.00-0.00 / kg
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Celastrol; Common Threewingnut root extract
34157-83-0
- US $0.00-0.00 / kg
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.