tetrathiomolybdate
- CAS No.
- 16330-92-0
- Chemical Name:
- tetrathiomolybdate
- Synonyms
- THIOMOLYBDATE;tetrathiomolybdate;tetrathiomolybdate(2-);Tetrathioxomolybdate(2-);18198-15-7 (Di-hydrochloride salt);Molybdate(2-), tetrathioxo-, (T-4)- (9ci)
- CBNumber:
- CB41383469
- Molecular Formula:
- MoS4
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 16330-92-0.mol
| storage temp. | Store at -20°C |
|---|---|
| EWG's Food Scores | 1 |
| FDA UNII | 91U3TGV99T |
tetrathiomolybdate Chemical Properties,Uses,Production
Uses
Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db). Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].
Definition
ChEBI: Tetrathiomolybdate(2-) is a molybdenum coordination entity. It has a role as a copper chelator.
in vivo
Tetrathiomolybdate (0.2 mg/mouse/day; p.o.; for 10 weeks) protects mice from collagen-induced arthritis with preventive effect[1].
Tetrathiomolybdate (0.03 mg/mL; medicined in water; p.o.; 8 weeks) inhibits the progress of collagen-induced arthritis in mice by reducing swelling and erythema[1].
| Animal Model: | Collagen-induced arthritis model in mice[1] |
| Dosage: | 0.2 mg/mouse/day or 0.03 mg/mL, added in water |
| Administration: | Oral gavage, for 10 weeks; Collagen injected at weeks 2 |
| Result: | Showed significant preventive effect and protective effect in mice. |
References
[1] Zeng C, et al. Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. Exp Biol Med (Maywood). 2008 Aug;233(8):1021-5. DOI:10.3181/0801-RM-10
tetrathiomolybdate Preparation Products And Raw materials
Raw materials
Preparation Products
tetrathiomolybdate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| JinOu Biomedical (Nanjing) Co., Ltd. | 13000000000 | jinoupharma@163.com | China | 11721 | 58 |
| Changzhou Bojia Biomedical Technology Co., Ltd. | 2122619822 | czbjpharma@126.com | China | 18478 | 58 |
| Taizhou Zhongzhi Biotechnology Co., Ltd | 13012344321 | 3995296515@qq.com | China | 7996 | 58 |