6-Chloroguanine
- CAS No.
- 10310-21-1
- Chemical Name:
- 6-Chloroguanine
- Synonyms
- 2-AMINO-6-CHLOROPURINE;6-Chloro-7H-purin-2-amine;2-amino-6-chloro-purin;6-CHLORO-2-AMINOPURINE;9H-PURIN-2-AMINE, 6-CHLORO-;2-AMINO-6-CHLOROPURINE (2A6ClP);AURORA KA-689;6-CHLOROGUANINE;TIMTEC-BB SBB003863;2-AMino-6-chlorpurin
- CBNumber:
- CB4143631
- Molecular Formula:
- C5H4ClN5
- Molecular Weight:
- 169.57
- MDL Number:
- MFCD00075252
- MOL File:
- 10310-21-1.mol
- MSDS File:
- SDS
Melting point | >300 °C (lit.) |
---|---|
Boiling point | 279.76°C (rough estimate) |
Density | 1.4937 (rough estimate) |
refractive index | 1.6110 (estimate) |
storage temp. | 2-8°C |
solubility | Solubility in 1mol/L NaOH |
form | Powder |
pka | 6.65±0.20(Predicted) |
color | White to yellow |
Water Solubility | 1.7 g/L (20 ºC) |
BRN | 9626 |
InChI | InChI=1S/C5H4ClN5/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H3,7,8,9,10,11) |
InChIKey | RYYIULNRIVUMTQ-UHFFFAOYSA-N |
SMILES | N1C2C(=NC(N)=NC=2Cl)NC=1 |
CAS DataBase Reference | 10310-21-1(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 83V03P835E |
EPA Substance Registry System | 6-Chloro-2-aminopurine (10310-21-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P201-P202-P261-P264b-P271-P280i-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P362+P364-P403+P233-P501c | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 20/21/22-36/37/38 | |||||||||
Safety Statements | 22-24/25-36-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | UO7502000 | |||||||||
F | 10 | |||||||||
Hazard Note | Irritant/Keep Cold | |||||||||
HazardClass | IRRITANT, KEEP COLD | |||||||||
HS Code | 29339900 | |||||||||
NFPA 704 |
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6-Chloroguanine price More Price(53)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR2861 | Famciclovir Related Compound F pharmaceutical secondary standard, certified reference material | 10310-21-1 | 50MG | $485 | 2024-03-01 | Buy |
Sigma-Aldrich | 109789 | 2-Amino-6-chloropurine ≥99% | 10310-21-1 | 1g | $26 | 2024-03-01 | Buy |
Sigma-Aldrich | 109789 | 2-Amino-6-chloropurine ≥99% | 10310-21-1 | 5g | $31.2 | 2024-03-01 | Buy |
TCI Chemical | A1407 | 2-Amino-6-chloropurine >98.0%(HPLC)(T) | 10310-21-1 | 1g | $34 | 2024-03-01 | Buy |
TCI Chemical | A1407 | 2-Amino-6-chloropurine >98.0%(HPLC)(T) | 10310-21-1 | 5g | $101 | 2024-03-01 | Buy |
6-Chloroguanine Chemical Properties,Uses,Production
Description
6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.
Description
2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).
Chemical Properties
white to light yellow crystal powder
Uses
2-Amino-6-chloropurine may be used:
- in the enzymatic synthesis of 2′-deoxyguanosine
- in the synthesis of 9-alkyl purines
- in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases
Uses
2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.
Definition
ChEBI: 6-chloroguanine is an organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6. It is a member of 2-aminopurines and an organochlorine compound.
General Description
2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.
Synthesis
Preparation of 2-amino-6-chloropurine:
Diacetyl guanine (8.0g, 0.034 moles), triethyimethylammonium chloride (15.45g, 0.102 moles), and triethylamine (4.74 mis, 0.034 moles) were heated together with stirring in acetonitrile (70mls) to 50°C. Phosphorus oxychioride (6.34 mis, 0.068 moles) was then added and stirring continued for 4 hours. The reaction mixture was cooled and then added to aqueous sodium hydroxide solution (20g in 300mls water). The reaction mixture was heated to 80°C for 2 hours and then the volume made up to 300 mis with water. The mixture was cooled to 25°C and the pH adjuster to 7 using 10% hydrochloric acid. The resulting slurry was stirred for fifteen minutes and the product filtered off and washed with water 30 mis and then dried at 80°C under vacuum to give a cream/off white coloured product, 2-amino-6-chioropurine 4.69 g (74.6% yield).
6-Chloroguanine Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hangzhou Measure Life Technology Co., LTD | +8613343730176 | 2924244016@qq.com | China | 83 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12452 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 | daisy@crovellbio.com | China | 5831 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20296 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 983 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16920 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21669 | 55 |
View Lastest Price from 6-Chloroguanine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-16 | 6-Chloroguanine
10310-21-1
|
US $0.00 / Kg/Drum | 100g/Bag | 99% | 100mt/year | Jinan Finer Chemical Co., Ltd | |
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2024-08-16 | 6-Chloroguanine
10310-21-1
|
US $0.00 / Kg/Drum | 1KG | 99%min | 10 TONS | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-07 | 6-Chloroguanine
10310-21-1
|
US $0.00-0.00 / kg | 1kg | 98% | 500kg per month | Yunbio Tech Co.,Ltd. |
-
- 6-Chloroguanine
10310-21-1
- US $0.00 / Kg/Drum
- 99%
- Jinan Finer Chemical Co., Ltd
-
- 6-Chloroguanine
10310-21-1
- US $0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 6-Chloroguanine
10310-21-1
- US $0.00-0.00 / kg
- 98%
- Yunbio Tech Co.,Ltd.
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