4-Amino-3,5-dichloropyridine N-oxide
- CAS No.
- 91872-02-5
- Chemical Name:
- 4-Amino-3,5-dichloropyridine N-oxide
- Synonyms
- Roflumilast Impurity 17;4-Amino-3,5-dichloropyridine N-oxide;3,5-dichloro-4-aminopyridine 1-oxide;4-Pyridinamine, 3,5-dichloro-, 1-oxide
- CBNumber:
- CB41501469
- Molecular Formula:
- C5H4Cl2N2O
- Molecular Weight:
- 179
- MDL Number:
- MOL File:
- 91872-02-5.mol
| Melting point | 210 °C (decomp) |
|---|---|
| Boiling point | 391.6±37.0 °C(Predicted) |
| Density | 1.66±0.1 g/cm3(Predicted) |
| pka | 2.25±0.10(Predicted) |
| FDA UNII | G9KH0SR06F |
4-Amino-3,5-dichloropyridine N-oxide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A632005 | 4-Amino-3,5-dichloropyridineN-Oxide | 91872-02-5 | 10mg | $285 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0358694 | 4-AMINO-3,5-DICHLOROPYRIDIN-1-IUM-1-OLATE 95.00% | 91872-02-5 | 5MG | $500.21 | 2021-12-16 | Buy |
4-Amino-3,5-dichloropyridine N-oxide Chemical Properties,Uses,Production
Preparation
4-amino-3,5-dichloropyridine-N-oxide is prepared by the following steps:A sealed Carius tube containing 4-nitro-3,5-dichloropyridine-N-oxide (36) (0.4 g, 1.9 mmol), aqueous ammonia (1 cm3 of 0.88 gi-l solution) and acetonitrile (1 cm3) was heated in a rotating oil bath at 70 OC for 3 h. The mixture was filtered giving a solid (0.1 g) and a filtrate, which was extracted into DCM, dried (MgS04) and evaporated giving a residue (0.0 g). The solid obtained from the filtration was recrystallised from hot methanol giving 4-amino-3,5-dichloropyridine-N-oxide (0.1 g, 30%), m.p. 210 oC from MeOH) (M+ found 177.9701. C5H4Cl2N20 requires M+ 177.9701); IR spectra no. 30; mass spectra no. 37; nmr spectrum no. 45.
Uses
4-Amino-3,5-dichloropyridine N-Oxide is the impurity of the drug Roflumilast (R639700), which is a selective phosphodiesterase 4(PDE4) inhibitor, antiasthmatic.
4-Amino-3,5-dichloropyridine N-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 13503 | 58 |
| sgtlifesciences pvt ltd | +8617013299288 | dj@sgtlifesciences.com | China | 12373 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 3868 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9891 | 58 | |
| Jinan Kaixi Biotechnology Co., Ltd. | 13370511208; 15853141736 | 461667177@qq.com | China | 565 | 55 |
| Shanghai Rlavie Technology Co., Ltd. | 021-021-67759270 17717059219 | sales@rlavie.com | China | 1094 | 55 |
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