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| 4-Amino-3,5-dichloropyridine N-oxide Basic information | Preparation |
| 4-Amino-3,5-dichloropyridine N-oxide Chemical Properties |
Melting point | 210 °C (decomp) | Boiling point | 391.6±37.0 °C(Predicted) | density | 1.66±0.1 g/cm3(Predicted) | pka | 2.25±0.10(Predicted) |
| 4-Amino-3,5-dichloropyridine N-oxide Usage And Synthesis |
Preparation | 4-amino-3,5-dichloropyridine-N-oxide is prepared by the following steps:A sealed Carius tube containing 4-nitro-3,5-dichloropyridine-N-oxide (36) (0.4 g, 1.9 mmol), aqueous ammonia (1 cm3 of 0.88 gi-l solution) and acetonitrile (1 cm3) was heated in a rotating oil bath at 70 OC for 3 h. The mixture was filtered giving a solid (0.1 g) and a filtrate, which was extracted into DCM, dried (MgS04) and evaporated giving a residue (0.0 g). The solid obtained from the filtration was recrystallised from hot methanol giving 4-amino-3,5-dichloropyridine-N-oxide (0.1 g, 30%), m.p. 210 oC from MeOH) (M+ found 177.9701. C5H4Cl2N20 requires M+ 177.9701); IR spectra no. 30; mass spectra no. 37; nmr spectrum no. 45. | Uses | 4-Amino-3,5-dichloropyridine N-Oxide is the impurity of the drug Roflumilast (R639700), which is a selective phosphodiesterase 4(PDE4) inhibitor, antiasthmatic. |
| 4-Amino-3,5-dichloropyridine N-oxide Preparation Products And Raw materials |
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