BIM 23056
- CAS No.
- 150155-61-6
- Chemical Name:
- BIM 23056
- Synonyms
- BIM 23056;M.W. 1232.49 C71H81N11O9;D-PHE-PHE-TYR-D-TRP-LYS-VAL-PHE-D-NAL-NH2;D-Phe-Phe-Tyr-D-Trp-Lys-VaL-Phe-D-Nal-NH2 trifluoroacetate salt;D-Alaninamide, D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)-
- CBNumber:
- CB4153548
- Molecular Formula:
- C71H81N11O9
- Molecular Weight:
- 1232.47
- MDL Number:
- MOL File:
- 150155-61-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| WGK Germany | 3 |
|---|---|
| Toxicity | TDLo ice-rat: 45.415 mg/kg JPETAB 293,1099,2000 |
BIM 23056 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B4310 | BIM 23056 ≥95% (HPLC) | 150155-61-6 | 1mg | $360 | 2024-03-01 | Buy |
| Usbiological | 254763 | BIM 23056 | 150155-61-6 | 1mg | $516 | 2021-12-16 | Buy |
| ApexBio Technology | B5196 | BIM 23056 | 150155-61-6 | 1mg | $377 | 2021-12-16 | Buy |
BIM 23056 Chemical Properties,Uses,Production
Biological Activity
somatostatin (srif) is a cyclic tetradecapeptide that was originally isolated from mammalian hypothalamus and characterized as a physiological regulator of gh secretion from the anterior pituitary. bim 23056 is a novel linear peptide of srif sstr3 antagnist.
Safety Profile
A poison by intracerebral route. When heated to decomposition it emits toxic vapors of NOx.
in vitro
bim 23056 bound to sstr3 with subnanomolar affinities. bim 23056 displayed remarkable selectivity for sstr3, not interacting significantly with either sstr1 or sstr2 at concentrations as high as 1 μm. bim 23056 was 30,000-fold selective for sstr3, which maks it a ligand of choice for future studies on sstr3 [1]. in addition, it has been found that bim 23056 behaves as a potent and surmountable antagonist at the human recombinant sst5 receptor. such antagonism was specific for the sst5 receptor as bim 23056 did not inhibit [ca2+], or ins(1,4,5)p3 increases in response to utp [2].
IC 50
0.02 nm for sstr3
References
[1] raynor k, murphy wa, coy dh, taylor je, moreau jp, yasuda k, bell gi, reisine t. cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. mol pharmacol. 1993 jun;43(6):838-44.
[2] wilkinson gf, thurlow rj, sellers la, coote je, feniuk w, humphrey pp. potent antagonism by bim-23056 at the human recombinant somatostatin sst5 receptor. br j pharmacol. 1996 jun;118(3):445-7.
BIM 23056 Preparation Products And Raw materials
Raw materials
Preparation Products
BIM 23056 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Creative Peptides | info@creative-peptides.com | United States | 6084 | 56 | |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | eric@peptidego.com | China | 6525 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Wuxi Helen Biotechnology Co., Ltd., | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 14092 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |