| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:BIM 23056
CAS:150155-61-6
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | BIM 23056 Basic information |
| Product Name: | BIM 23056 | | Synonyms: | BIM 23056;D-PHE-PHE-TYR-D-TRP-LYS-VAL-PHE-D-NAL-NH2;D-Phe-Phe-Tyr-D-Trp-Lys-VaL-Phe-D-Nal-NH2 trifluoroacetate salt;M.W. 1232.49 C71H81N11O9;D-Alaninamide, D-phenylalanyl-L-phenylalanyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-phenylalanyl-3-(2-naphthalenyl)- | | CAS: | 150155-61-6 | | MF: | C71H81N11O9 | | MW: | 1232.47 | | EINECS: | | | Product Categories: | Somatostatin receptor | | Mol File: | 150155-61-6.mol |  |
| | BIM 23056 Chemical Properties |
| Boiling point | 1544.6±65.0 °C(Predicted) | | density | 1.271±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | H2O: >1mg/mL | | form | solid | | pka | 9.82±0.15(Predicted) | | color | white |
| WGK Germany | 3 | | Toxicity | TDLo ice-rat: 45.415 mg/kg JPETAB 293,1099,2000 |
| | BIM 23056 Usage And Synthesis |
| Biological Activity | somatostatin (srif) is a cyclic tetradecapeptide that was originally isolated from mammalian hypothalamus and characterized as a physiological regulator of gh secretion from the anterior pituitary. bim 23056 is a novel linear peptide of srif sstr3 antagnist. | | Safety Profile | A poison by intracerebral route. When heated to decomposition it emits toxic vapors of NOx. | | in vitro | bim 23056 bound to sstr3 with subnanomolar affinities. bim 23056 displayed remarkable selectivity for sstr3, not interacting significantly with either sstr1 or sstr2 at concentrations as high as 1 μm. bim 23056 was 30,000-fold selective for sstr3, which maks it a ligand of choice for future studies on sstr3 [1]. in addition, it has been found that bim 23056 behaves as a potent and surmountable antagonist at the human recombinant sst5 receptor. such antagonism was specific for the sst5 receptor as bim 23056 did not inhibit [ca2+], or ins(1,4,5)p3 increases in response to utp [2]. | | IC 50 | 0.02 nm for sstr3 | | references | [1] raynor k, murphy wa, coy dh, taylor je, moreau jp, yasuda k, bell gi, reisine t. cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides. mol pharmacol. 1993 jun;43(6):838-44.
[2] wilkinson gf, thurlow rj, sellers la, coote je, feniuk w, humphrey pp. potent antagonism by bim-23056 at the human recombinant somatostatin sst5 receptor. br j pharmacol. 1996 jun;118(3):445-7. |
| | BIM 23056 Preparation Products And Raw materials |
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