Diisobutylaluminium hydride
- CAS No.
- 1191-15-7
- Chemical Name:
- Diisobutylaluminium hydride
- Synonyms
- DIBAL-H;Dibal;DIISOBUTYLALUMINUM HYDRIDE;DIBAH;Diisobutylaluminum;Bis(2-methylpropyl)alumane;Bisisobutylaluminum;Diisobutylaluminum hydrid;diisobutylaluminum hydride solution;DiisobutylaluMinuM hydride solution 1.0 M in cyclohexane
- CBNumber:
- CB4171924
- Molecular Formula:
- C8H19Al
- Molecular Weight:
- 142.22
- MDL Number:
- MFCD00008928
- MOL File:
- 1191-15-7.mol
- MSDS File:
- SDS
| Melting point | -70 °C |
|---|---|
| Boiling point | 65 °C |
| Density | 1.23 g/mL at 25 °C |
| vapor pressure | 13.3Pa at 90℃ |
| Flash point | 40 °F |
| storage temp. | 2-8°C |
| solubility | Miscible with organic solvents. |
| form | Solution |
| Specific Gravity | 0.860 |
| color | Clear |
| Water Solubility | vigorous reaction |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| Sensitive | Air Sensitive/Heat Sensitive |
| BRN | 4123663 |
| Exposure limits |
ACGIH: TWA 20 ppm OSHA: Ceiling 300 ppm; TWA 200 ppm NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3) |
| InChIKey | AZWXAPCAJCYGIA-UHFFFAOYSA-N |
| LogP | 4.22 |
| CAS DataBase Reference | 1191-15-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | H2EJ47H11A |
| NIST Chemistry Reference | Diisobutylaluminum hydride(1191-15-7) |
| EPA Substance Registry System | Diisobutylaluminum hydride (1191-15-7) |
| UNSPSC Code | 12352001 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H250-H260-H304-H314-H336-H361d-H373-H412 | |||||||||
| Precautionary statements | P210-P231+P232-P280-P301+P310+P331-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310-P370+P378 | |||||||||
| Hazard Codes | F,T,C,N | |||||||||
| Risk Statements | 14/15-17-35-40-67-65-63-48/20-11-34-19-62-51/53-23/24/25-20/21/22-15-14-50/53-37-22 | |||||||||
| Safety Statements | 26-43-45-62-46-36/37/39-29-16-61-27-9 | |||||||||
| RIDADR | UN 3399 4.3/PG 1 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | BD0710000 | |||||||||
| F | 1-4.3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 4.3 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29319090 | |||||||||
| Hazardous Substances Data | 1191-15-7(Hazardous Substances Data) | |||||||||
| NFPA 704 |
|
Diisobutylaluminium hydride price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 214981 | Diisobutylaluminum hydride solution 1.0?M in THF | 1191-15-7 | 4X25ML | $102 | 2024-03-01 | Buy |
| Sigma-Aldrich | 214981 | Diisobutylaluminum hydride solution 1.0?M in THF | 1191-15-7 | 18L | $2160 | 2024-03-01 | Buy |
| Sigma-Aldrich | 190306 | Diisobutylaluminum hydride solution 1.0M in hexanes | 1191-15-7 | 100ml | $62.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 190306 | Diisobutylaluminum hydride solution 1.0M in hexanes | 1191-15-7 | 4x100ml | $215 | 2024-03-01 | Buy |
| Alfa Aesar | H37108 | Diisobutylaluminumhydride,1.1Mincyclohexane packagedunderNitrogeninresealableAcroSeal[tbottles | 1191-15-7 | 100ml | $64.5 | 2024-03-01 | Buy |
Diisobutylaluminium hydride Chemical Properties,Uses,Production
Description
Diisobutylaluminium hydride (DIBALH, DIBAL, DIBAL-H or DIBAH) is a reducing agent with the formula (i-Bu2AlH)2, where i-Bu represents isobutyl (-CH2CH(CH3)2). It can be used for various homogeneous reductions such as alkynes to alkenes, esters or nitriles to aldehydes. It is available commercially as the neat reagent and as a solution in several different solvents (hexane, dichloromethane, tetrahydrofuran, etc.). The neat reagent is a liquid and is supplied in metal cylinders. It is pyrophoric and highly reactive and therefore must be handled with great care. The molar solutions in organic solvents are more stable and easier to handle provided that the normal precautions are taken for working with air-sensitive compounds. They must all be handled in an atmosphere free from oxygen and water. Commonly used solvents for diisobutylaluminium hydride are dichloromethane, diglyme, dioxane and tetrahydrofuran. Even when the substrate is not completely soluble in these solvents successful reductions can be accomplished.
Chemical Properties
Diisobutylaluminium hydride, also known as Dibal. colorless liquid. Viscosity 18.0mPa-s(25℃). Reacts violently with water to form hydrogen and isobutane. Tetrahydrofuran is not suitable as Dibal solvent, because the two react to produce coordination compounds. Diisobutylaluminium hydride is a useful reducing agent in organic synthesis. It can reduce ketones, carboxylic acids and esters to the corresponding alcohols. Dibal can also reduce lactones to o-hydroxy lactones.
Uses
Diisobutylaluminum hydride is used as reducing agent in pharmaceuticals. It is also used as raw material in organic synthesis, agrochemicals and dyestuffs.
Uses
Diisobutylaluminum hydride (DIBAL-H) is a common reducing agent to reduce aldehydes, ketones, esters, acids and acid chlorides to the corresponding alcohols. Some of the applications are:
Synthesis of α-acetoxy ethers by reduction and subsequent acetylation of esters.
Synthesis of coniferyl, sinapyl, and p-coumaryl alcohol by selective reduction of corresponding cinnamate esters.
Reduction of secondary phosphine oxides (SPOs) to the corresponding phosphines.
DIBAL-H can also be used in the hydroalumination of alkene and alkynes.
Uses
Diisobutylaluminum hydride is commonly used as a reducing agent in organic synthesis.
Diisobutylaluminum hydride can be used in the following protocols:
As a promotor of Tishchenko reaction of aldehydes.
Conversion of benzylidene acetals of 1,2-and 1,3-glycols to the corresponding monobenzyl ethers of the glycols.
To generate a novel chiral reducing agent based on (S)-proline for the asymmetric reduction of prochiral ketones.
Flammability and Explosibility
Spontaneously flammable in air (pyrophoric)
reaction suitability
reagent type: reductant
Safety Profile
Mddly toxic by inhalation. Dangerous fire hazard; iptes spontaneously in air. To fight fire, do not use water, foam, or halogenated extinguisking agents. See also HYDRIDES and ALUMINUM COMPOUNDS.
Diisobutylaluminium hydride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531157085 | abby@chuanghaibio.com | China | 8808 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3883 | 58 |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +86-519-85525359 +86-15995072465 | sales@xuanmingchem.com | China | 914 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
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View Lastest Price from Diisobutylaluminium hydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-23 | Diisobutylaluminium hydride
1191-15-7
|
US $10.00 / KG | 1KG | 99% | 5tons | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-09 | Diisobutylaluminium hydride
1191-15-7
|
US $30.00-110.00 / g | 1g | 99% | 1000kg/month | Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | |
 |
2024-07-15 | Diisobutylaluminium hydride
1191-15-7
|
US $0.10 / KG | 1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- Diisobutylaluminium hydride
1191-15-7
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Diisobutylaluminium hydride
1191-15-7
- US $30.00-110.00 / g
- 99%
- Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
-
- Diisobutylaluminium hydride
1191-15-7
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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