DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- CAS No.
- 104992-55-4
- Chemical Name:
- DMT-2'O-TBDMS-rA(bz) Phosphoramidite
- Synonyms
- Bz-rA Phosphoramidite;2'-TBDMS-A CEP;N-Benzoyl-5-O-(4;RNA N-Bz A Amidite;8-Aza-7-deaza-A CEP;DMT-2'-0-TBDMS-rA(BZ);DMT-2'-O-TBDMS-A(Bz)-CE;2’-OTBDMS-rA(Bz) Amidite;N-diisopropyl)phosphoramidite;2TBDMS-rA(BZ) Phosphoramidite
- CBNumber:
- CB41871629
- Molecular Formula:
- C53H66N7O8PSi
- Molecular Weight:
- 988.19
- MDL Number:
- MFCD00080297
- MOL File:
- 104992-55-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
WGK Germany | 3 |
HS Code | 29349990 |
DMT-2'O-TBDMS-rA(bz) Phosphoramidite price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A211050 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) | 104992-55-4 | 2g | $188 | 2024-03-01 | Buy |
Sigma-Aldrich | A211050 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for (?KTA? and OligoPilot?) | 104992-55-4 | 10g | $916 | 2024-03-01 | Buy |
Sigma-Aldrich | A211040 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade | 104992-55-4 | 5G | $372 | 2024-03-01 | Buy |
Sigma-Aldrich | A211040 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite configured for MerMade | 104992-55-4 | 10g | $941 | 2024-03-01 | Buy |
Sigma-Aldrich | A211000 | DMT-2′O-TBDMS-rA(bz) Phosphoramidite | 104992-55-4 | 100g | $7590 | 2024-03-01 | Buy |
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Chemical Properties,Uses,Production
Uses
N-Benzoyl-5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]adenosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite can be used as Organic synthesis intermediates and pharmaceutical intermediates are mainly used in laboratory research and development processes and chemical production processes.
Uses
DMT-2''O-TBDMS-rA(bz) Phosphoramidite (DMT-2'O-TBDMS-rA(bz) Phosphoramidite) is a 2''-O-Protected ribonucleoside phosphoramidite used as a key raw material for the automated solid-supported synthesis of oligonucleotide-based drugs. It is also used to synthesize 2''-O-guanidinopropyl-modified nucleoside phosphoramidites to incorporate into siRNAs targeting hepatitis B virus.
Synthesis
To a solution of 72 (12.0 g, 15.2 mmoi) in DIPEA (15 ml) and DCM (30 mL) is added DMAP (744 mg, 6.09 rnrnol) and 2cyanoethyl JV.Ndiisopropylchlorophosphoramidite (5.41 g, 22.9 rnmoi) at 25 ℃. After stirring for 2 hours, the mixture is purified directly by basic silica gel column chromatography (EAIPE 1/4 toi/1) to give DMT-2'O-TBDMS-rA(bz) Phosphoramidite as a white solid (13.0 g. 86% yield)
DMT-2'O-TBDMS-rA(bz) Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Allbiosyn Biotechnology Co.,Ltd. | +8618666985712 | info@allbiosyn.com | China | 286 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
Yunbio Tech Co.,Ltd. | +86-010-60605551 +86-18046518538 | yunbiochem@126.com | China | 321 | 58 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 | sales@unisyn.cn | CHINA | 332 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from DMT-2'O-TBDMS-rA(bz) Phosphoramidite manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2024-08-08 | N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE
104992-55-4
|
US $0.00 / mg | 100mg | ≥98% | 20tons | Hefei Huana Biomedical Technology Co.,Ltd. | |
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2023-03-22 | 2'-O-TBDMS-A(Bz) CE Phosphoramidite;Bz-rA
104992-55-4
|
US $100.00 / kg | 0.009999999776482582kg | 99% | 5tons | SHANGHAI NOVRIBO BIOTECH | |
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2022-09-24 | Bz-rA Phosphoramidite
104992-55-4
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- N6-Bz-5'-O-DMT-2'-O-TBDMS-A-CE
104992-55-4
- US $0.00 / mg
- ≥98%
- Hefei Huana Biomedical Technology Co.,Ltd.
-
- 2'-O-TBDMS-A(Bz) CE Phosphoramidite;Bz-rA
104992-55-4
- US $100.00 / kg
- 99%
- SHANGHAI NOVRIBO BIOTECH
-
- Bz-rA Phosphoramidite
104992-55-4
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.