Tetrazole | 288-94-8

Tetrazole Properties

Melting point	156-158°C
Boiling point	220℃
Density	0.798 g/mL at 20 °C
RTECS	UW7370000
refractive index	n20/D 1.348
Flash point	5 °C
storage temp.	Room temperature.
solubility	DMSO, Methanol
form	Liquid
pka	4.9(at 25℃)
color	Cream to orange
Water Solubility	Soluble
Decomposition	220°C
BRN	105799
Stability	Stable at RT
InChIKey	KJUGUADJHNHALS-UHFFFAOYSA-N
CAS DataBase Reference	288-94-8(CAS DataBase Reference)
FDA UNII	D34J7PAT68
NIST Chemistry Reference	1H-Tetrazole(288-94-8)
EPA Substance Registry System	1H-Tetrazole (288-94-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS02,GHS07
Signal word	Danger
Hazard statements	H303-H312-H225-H302-H319-H332
Precautionary statements	P210-P305+P351+P338-P261-P280-P303+P361+P353-P501a
Hazard Codes	F,Xn,E
Risk Statements	11-20/21/22-36-5-4
Safety Statements	16-26-36-36/37-35-15
RIDADR	UN 1993 3/PG 2
WGK Germany	3
F	3-4.15-10
HazardClass	4.1
PackingGroup	III
HS Code	29339900

Tetrazole price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	88185	Tetrazole solution for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile	288-94-8	100ml	$178	2024-03-01	Buy
Sigma-Aldrich	88185	Tetrazole solution for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile	288-94-8	500ml	$803	2024-03-01	Buy
Alfa Aesar	J61034	1H-Tetrazole, 0.45M in acetonitrile	288-94-8	200ml	$299	2024-03-01	Buy
Alfa Aesar	J61034	1H-Tetrazole, 0.45M in acetonitrile	288-94-8	450ml	$599	2024-03-01	Buy
TRC	T307505	1H-Tetrazole, 0.45M in acetonitrile	288-94-8	25ml	$85	2021-12-16	Buy

Product number	Packaging	Price	Buy
88185	100ml	$178	Buy
88185	500ml	$803	Buy
J61034	200ml	$299	Buy
J61034	450ml	$599	Buy
T307505	25ml	$85	Buy

Tetrazole Chemical Properties,Uses,Production

Description

Tetrazole is a class of synthetic organic heterocyclic compound containing a 5-member ring of four nitrogen atoms and one carbon atom. It appears as an odorless white to light-yellow crystalline powder. It has several pharmaceutical applications. Tetrazole compound can act as a bioisotere for the carboxylate group, angiotensin II receptor blockers such as losartan and candesartan as well as dimethyl thiazolyl diphenyl tetrazolium bromide (MTT), which can be used in MTT assay for quantifying the respiratory activity of liver cells. It can also be used in DNA assays. In addition, Tetrazole derivatives have also been used in explosives such as TNT or high performance solid rocket propellant formulations. Tetrazole can be synthesized through the reaction between anhydrous hydrazoic acid and hydrogen cyanide under pressure.

References

https://en.wikipedia.org/wiki/Tetrazole
https://pubchem.ncbi.nlm.nih.gov/compound/1H-Tetrazole#section=Information-Sources

Chemical Properties

white crystals or crystalline powder

Uses

Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.

Preparation

The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.

Definition

ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.

Application

1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.

General Description

Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.

Health Hazard

Fire may produce irritating, corrosive and/or toxic gases.

Fire Hazard

MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.

Purification Methods

Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]

Tetrazole synthesis

Synthesis of Tetrazole from Triethyl orthoformate

Tetrazole Preparation Products And Raw materials

Raw materials

1H-TETRAZOLE-5-CARBOXYLIC ACID tetrazolo[1,5-a]pyridine-7-carboxylic acid

Preparation Products

Cilostazol Irbesartan Cefoperazone Cefteram pivoxil Valsartan

Ropinirole 2H-Tetrazol-2-amine 2H-Tetrazole, 2-methyl-

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Tetrazole Suppliers

Global( 583)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	info@allgreenchem.com	China	5996	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12832	58
XINXIANG RUNYU MATERIAL CO., LTD.	+86-13592593621; +8613592593621	sales@runvmat.com	China	396	58
Hebei Weibang Biotechnology Co., Ltd	+8617732866630	bess@weibangbio.com	China	18148	58
Shandong Juchuang Chemical Co., LTD	+undefined15030412209	admin@juchuangchem.com	China	333	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883 +86-16264648883	niki@zlchemi.com	China	3001	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29793	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	8791	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60

Supplier	Advantage
Henan Allgreen Chemical Co.,LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
XINXIANG RUNYU MATERIAL CO., LTD.	58
Hebei Weibang Biotechnology Co., Ltd	58
Shandong Juchuang Chemical Co., LTD	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from Tetrazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-01-08	Tetrazole 288-94-8	US $10.00 / kg	1kg	99%	20 ton	Hebei Zhuanglai Chemical Trading Co Ltd
2024-12-17	Tetrazole 288-94-8	US $0.00-0.00 / kg	1kg	99%	500kg	XINXIANG RUNYU MATERIAL CO., LTD.
2024-11-04	Tetrazole 288-94-8	US $0.00-0.00 / KG	1KG	99%	500000kg	Hebei Weibang Biotechnology Co., Ltd

Tetrazole
288-94-8
US $10.00 / kg
99%
Hebei Zhuanglai Chemical Trading Co Ltd

Tetrazole
288-94-8
US $0.00-0.00 / kg
99%
XINXIANG RUNYU MATERIAL CO., LTD.

Tetrazole
288-94-8
US $0.00-0.00 / KG
99%
Hebei Weibang Biotechnology Co., Ltd

Tetrazole Spectrum

Tetrazole(288-94-8)MS Tetrazole(288-94-8)¹HNMR Tetrazole(288-94-8)¹³CNMR Tetrazole(288-94-8)IR1 Tetrazole(288-94-8)IR2

288-94-8(Tetrazole)Related Search:

5-Mercapto-1-methyltetrazole Nitrotetrazolium blue chloride 1H-Tetrazole-1-acetic acid 2,3,5-Triphenyltetrazolium chloride 5-Phenyltetrazole

5-(2,4-DICHLOROPHENYL)-1H-TETRAZOLE,5-(2,4-DICHLOROPHENYL)-1H-TETRAZOLE,5-(2,4-DICHLOROPHENYL)-1H-TETRAZOLE 5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE,5-(2,6-DICHLOROPHENYL)-1H-TETRAZOLE 1H-TETRAZOLE, 1-PHENYL-5-THIOL 1-(M-SULFOPHENYL)-5-MERCAPTO-1H-TETRAZOLE SODIUM SALT 5-(2,5-DICHLOROPHENYL)-1H-TETRAZOLE,5-(2,5-DICHLOROPHENYL)-1H-TETRAZOLE

5-(2,3-DICHLOROPHENYL)-1H-TETRAZOLE,5-(2,3-DICHLOROPHENYL)TETRAZOLE,5-(2,3-DICHLOROPHENYL)-1H-TETRAZOLE,5-(2,3-DICHLOROPHENYL)TETRAZOLE 5-Mercapto-1H-tetrazole-1-methanesulfonic acid disodium salt 1H-TETRAZOLE-5-CARBOXYLIC ACID ETHYL ESTER SODIUM SALT 5-(Methylthio)-1H-tetrazole 1-[2-(Dimethylamino)ethyl]-1H-tetrazole-5-thiol

5-(2,6-DIFLUOROPHENYL)TETRAZOLE,5-(2,6-DIFLUOROPHENYL)TETRAZOLE 5-[2-(4-CHLORO-3,5-DIMETHYL-PYRAZOL-1-YL)-ETHYL]-2H-TETRAZOLE,5-[2-(4-CHLORO-3,5-DIMETHYL-PYRAZOL-1-YL)-ETHYL]-2H-TETRAZOLE 5-(2-BROMO-BENZYL)-2H-TETRAZOLE,5-(2-BROMO-BENZYL)-2H-TETRAZOLE

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