Amsacrine hydrochloride
- CAS No.
- 54301-15-4
- Chemical Name:
- Amsacrine hydrochloride
- Synonyms
- nsc141549;nci-c03190;M-AMSA, HCL;M-Amsacrine;Amsacrine HCI;META-AMSACRINE;AMSA hydrochloride;M-AMSA HYDROCHLORIDE;AMSACRINE HYDROCHLORIDE;acridinyl anisidide hydrochloride
- CBNumber:
- CB4236395
- Molecular Formula:
- C21H20ClN3O3S
- Molecular Weight:
- 429.92
- MDL Number:
- MFCD07799963
- MOL File:
- 54301-15-4.mol
- MSDS File:
- SDS
| Melting point | 197-199 °C(lit.) |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO: 10 mg/mL with heat and sonication |
| form | powder |
| color | red to brown |
| FDA UNII | U66HX4K4CO |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H317-H341-H351-H361d | |||||||||
| Precautionary statements | P202-P261-P264-P280-P301+P310-P302+P352 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | PB1081000 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
Amsacrine hydrochloride price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9809 | Amsacrine hydrochloride ≥98% (TLC), powder | 54301-15-4 | 10mg | $336 | 2024-03-01 | Buy |
| Sigma-Aldrich | A9809 | Amsacrine hydrochloride ≥98% (TLC), powder | 54301-15-4 | 50mg | $1220 | 2024-03-01 | Buy |
| TCI Chemical | A2777 | Amsacrine Hydrochloride >98.0%(HPLC) | 54301-15-4 | 20mg | $118 | 2024-03-01 | Buy |
| TCI Chemical | A2777 | Amsacrine Hydrochloride >98.0%(HPLC) | 54301-15-4 | 100mg | $349 | 2024-03-01 | Buy |
| Cayman Chemical | 22223 | Amsacrine (hydrochloride) ≥98% | 54301-15-4 | 5mg | $37 | 2024-03-01 | Buy |
Amsacrine hydrochloride Chemical Properties,Uses,Production
Uses
Amsacrine hydrochloride has been used:
- as a topoisomerase poison in bacteriophage T4 topoisomerase assay
- as a topoisomerase inhibitor in Drosophila cell line, Kc167
- as an antileukemia drug to test its effect on p53 transcriptional activity in tumor xenografts
- as a topoisomerase II poison in dose-response assays in C elegans
Biological Activity
amsacrine hydrochloride (amsidine, m-amsa) is an inhibitor of topoisomerase 2 [1].amsacrine hydrochloride is a chemotherapy drug of antineoplastic, used to treat some types of lymphoma and acute leukaemia. in addition, amsacrine hydrochloride has shown the sensitivities to the cancer cell lines with the ic50 values of 190.2±27.4ng/ml, 46.1±3.9ng/ml,22.6±3.1ng/ml, 11.8±2.0ng/ml, 5.0±0.4ng/ml, and 11.7±1.5ng/ml for three bladder cancer cell lines (ht1376,rt112, rt4) and three testis cancer cell lines(833k, susa, gh), respectively. and it has been found that the testis tumor cell lines are more sensitive to inhibiting by amsacrine hydrochloride than the bladder cell lines [1].
Biochem/physiol Actions
Amsacrine (m-AMSA) is a derivative of acridine and an antileukemia drug. It is an anticancer drug with antineoplastic activity that targets topoisomerase II. AMSA is an apoptosis inducer and favors the accumulation of double-stranded breaks (DSBs). It also inhibits the expression of matrix metallopeptidase 2 (MMP-2) and MMP-9 expression in leukemia cells by generating reactive oxygen species (ROS). AMSA serves as an adjuvant in trabeculectomy surgery.
in vivo
In animals treated with different doses of amsacrine (0.5-12 mg/kg), the frequencies of micronucleated polychromatic erythrocytes increase significantly after treatment with 9 and 12 mg/kg. Furthermore, the present study demonstrates for the first time that Amsacrine (mAMSA) has high incidences of clastogenicity and low incidences of aneugenicity whereas Nocodazole has high incidences of aneugenicity and low incidences of clastogenicity during mitotic phases in vivo[2].
IC 50
Topoisomerase II
References
[1] nelson em, tewey km, liu lf. mechanism of antitumor drug action: poisoning of mammalian dna topoisomerase ii on dna by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. proc natl acad sci u s a. 1984 mar;81(5):1361-5.
Amsacrine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12162 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
View Lastest Price from Amsacrine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Amsacrine hydrochloride
54301-15-4
|
US $39.00-72.00 / mg | 99.92% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-10 | Amsacrine hydrochloride
54301-15-4
|
US $1.00 / g | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- Amsacrine hydrochloride
54301-15-4
- US $39.00-72.00 / mg
- 99.92%
- TargetMol Chemicals Inc.
-
- Amsacrine hydrochloride
54301-15-4
- US $1.00 / g
- 99.0%
- Career Henan Chemical Co
54301-15-4(Amsacrine hydrochloride)Related Search:
1of4