6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE
- CAS No.
- 5396-25-8
- Chemical Name:
- 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE
- Synonyms
- 6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE;ACRIDINE, 6,9-DICHLORO-1,2,3,4-TETRAHYDRO-;6-Chloro-9-Chloro-1,2,3,4-Tetrahydroacridine
- CBNumber:
- CB42466963
- Molecular Formula:
- C13H11Cl2N
- Molecular Weight:
- 252.14
- MDL Number:
- MFCD11849267
- MOL File:
- 5396-25-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H413-H319-H335-H302-H315 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| NFPA 704 |
|
6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 30502 | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | 5396-25-8 | 50mg | $61 | 2024-03-01 | Buy |
| Cayman Chemical | 30502 | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | 5396-25-8 | 100mg | $111 | 2024-03-01 | Buy |
| Cayman Chemical | 30502 | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | 5396-25-8 | 25mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 30502 | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | 5396-25-8 | 250mg | $243 | 2024-03-01 | Buy |
| AK Scientific | 5430BA | 6,9-Dichloro-1,2,3,4-tetrahydroacridine | 5396-25-8 | 25mg | $133 | 2021-12-16 | Buy |
6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Chemical Properties,Uses,Production
Biological Activity
6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1 It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3
References
1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: Synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analoguesJ. Med. Chem.43(10)2007-2018(2000) 2.Digiacomo, M., Chen, Z., Wang, S., et al.Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of ADBioorg. Med. Chem. Lett.25(4)807-810(2015) 3.Li, S.Y., Jiang, N., Xie, S.S., et al.Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's diseaseOrg. Biomol. Chem.12(5)801-814(2014)
6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
6,9-DICHLORO-1,2,3,4-TETRAHYDROACRIDINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28817 | 58 |
| Biokitchen | 021-021-021-31663258 13795219287 | donghuanwen@126.com | China | 2002 | 58 |
| Sichuan BaiPeng Biotechnology Co., Ltd. | 028-65791793 18140026355 | 568470422@qq.com | China | 10003 | 58 |
| Aikon International Limited | 025-58851090 13611564524 | lwan@aikonchem.com | China | 15952 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 | malulu@leyan.com | China | 54986 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24647 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12582 | 58 |