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ChemicalBook >> CAS DataBase List >>N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Structure
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide structure
CAS No.
702675-74-9
Chemical Name:
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
Synonyms
BX 795;CS-544;BX795, >97%;BX795/BX-795;BX 795, >=98%;BX-795 hydrochloride;BX-795; BX 795; BX795.;BX-795 - CAS 702675-74-9 - Calbiochem;IKK,Inhibitor,BX795,BX-795,I kappa B kinase,inhibit,IκB kinase,PDK-1,BX 795,Autophagy;N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrr
CBNumber:
CB42484697
Molecular Formula:
C23H26IN7O2S
Molecular Weight:
591.47
MDL Number:
MFCD12546134
MOL File:
702675-74-9.mol
MSDS File:
SDS
Last updated:2024-11-01 18:09:03
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N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Properties

Melting point >163°C (dec.)
Density 1.644
storage temp. 2-8°C
solubility DMSO: soluble15mg/mL, clear
form powder
pka 12.57±0.70(Predicted)
color white to light brown
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey VAVXGGRQQJZYBL-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

WGK Germany  3

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0694 BX-795 hydrochloride ≥98% (HPLC) 702675-74-9 5mg $105 2024-03-01 Buy
Sigma-Aldrich 204001 BX-795 702675-74-9 10mg $225 2024-03-01 Buy
Cayman Chemical 14932 BX-795 ≥98% 702675-74-9 5mg $81 2024-03-01 Buy
Cayman Chemical 14932 BX-795 ≥98% 702675-74-9 10mg $152 2024-03-01 Buy
Sigma-Aldrich SML0694 BX-795 hydrochloride ≥98% (HPLC) 702675-74-9 25mg $255 2024-03-01 Buy
Product number Packaging Price Buy
SML0694 5mg $105 Buy
204001 10mg $225 Buy
14932 5mg $81 Buy
14932 10mg $152 Buy
SML0694 25mg $255 Buy

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Chemical Properties,Uses,Production

Description

3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that phosphorylates and activates a range of other kinases, including PKB, PKA, and certain isoforms of PKC. BX-795 is a potent, ATP-competitive inhibitor of PDK1 in vitro (IC50 = 11 nM) and in cells (IC50 = 300 nM). At comparable concentrations, BX-795 also inhibits ERK8, MAPK-interacting kinase 2, Aurora B, Aurora C, MAP/microtubule affinity-regulating kinases 1-4, TNF receptor associated factor-associated NF-κB activator-binding kinase 1, IκB kinase ε, and additional kinases.

Uses

BX-795 hydrochloride has been used to study the effect of kinase inhibition on human endogenous retroviruses (HERVs) transcription activation.

Definition

ChEBI: N-[3-[[5-iodo-4-[3-[[oxo(thiophen-2-yl)methyl]amino]propylamino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide is a member of ureas.

Biochem/physiol Actions

BX-795 competes for the ATP (adenosine triphosphate) binding pocket of 3-phosphoinositide-dependent kinase-1 (PDK1) with its substrate ATP. In vitro assays reveal that BX-795 might inhibit Unc-51 (serine/threonine-protein kinase)-like autophagy activating kinase (ULK1).

storage

Store at -20°C

References

Feldman et al. (2005) Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1; J. Biol. Chem.?280 19867 Bain et al. (2007) The selectivity of protein kinase inhibitors: a further update; Biochem.? J. 408 297 Clark et al. (2009) Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IkB Kinase ε; J.? Biol. Chem.?284 14136 Bai et al. (2015) BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest; Eur.? J. Pharmacol.?769 287 Choi et al. (2019) A pharmacogenomic analysis using L1000CDS2 identifies BX-795 as a potential anticancer drug for primary pancreatic ductal adenocarcinoma cells; Cancer Lett.?465 82 Scuderi et al. (2021) TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells; Oncol.? Res.?28 779 Sutlu et al. (2012) Inhibition of Intracellular Antiviral Defense Mechanisms Augments Lentiviral Transduction of Human Natural Killer Cells: Implications for Gene Therapy; Hum. Gene Ther.?23 1090 Allan et al. (2021) Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing e4x vivo expansion; Mol. Ther. Methods Clin. Dev.?20 559 Chockley et al. (2021) Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors; Cytotherapy?23 787 Lingyu et al. (2020) Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKε complex inhibitor BX795; J. Transl. Med.?18 363

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Suppliers

Global( 159)Suppliers
Supplier Tel Email Country ProdList Advantage
HangZhou RunYan Pharma Technology Co.,LTD. 		+8618882027439 sales2@runyanpharma.com China 302 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29886 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 965 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32038 58
Supplier Advantage
HangZhou RunYan Pharma Technology Co.,LTD. 		58
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Biochempartner 		58
Hubei xin bonus chemical co. LTD 		58
BOC Sciences 		58
Chongqing Chemdad Co., Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58

View Lastest Price from N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BX-795 pictures 2024-11-03 BX-795
702675-74-9
 US $0.00 / kg 1kg 99% HPLC 1000kg HangZhou RunYan Pharma Technology Co.,LTD.
BX795 pictures 2024-11-01 BX795
702675-74-9
 US $54.00-220.00 / mg 99.57% 10g TargetMol Chemicals Inc.
N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide pictures 2019-09-04 N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide
702675-74-9
 US $5.00 / KG 1KG 99% 1ton Career Henan Chemical Co
  • BX-795 pictures
  • BX-795
    702675-74-9
  • US $0.00 / kg
  • 99% HPLC
  • HangZhou RunYan Pharma Technology Co.,LTD.
  • BX795 pictures
  • BX795
    702675-74-9
  • US $54.00-220.00 / mg
  • 99.57%
  • TargetMol Chemicals Inc.

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide Spectrum

N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide(702675-74-9)1HNMR

702675-74-9(N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide)Related Search:

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N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX 795 N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)aMino]propyl]aMino]-2-pyriMidinyl]aMino]phenyl]-1-pyrrolidin BX795/BX-795 N-(3-(5-IODO-4-(3-(THIOPHENE-2-CARBOXAMIDO)PROPYLAMINO)PYRIMIDIN-2-YLAMINO)PHENYL)PYRROLIDINE-1-CARBOXAMIDE N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-795 BX-795 hydrochloride N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-Pyrrolidinecarboxamide hydrochloride BX795N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX 795, >=98% N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrr 1-Pyrrolidinecarboxamide,N-[3-[[5-iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]- BX-795; BX 795; BX795. CS-544 BX-795 - CAS 702675-74-9 - Calbiochem BX795, >97% N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide N-{3-[(5-iodo-4-{[3-(thiophen-2-ylformamido)propyl]amino}pyrimidin-2-yl)amino]phenyl}pyrrolidine-1-carboxamide N-[3-[[5-Iodo-4-[[3-[(2-thienylcarbonyl)amino]propyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide USP/EP/BP IKK,Inhibitor,BX795,BX-795,I kappa B kinase,inhibit,IκB kinase,PDK-1,BX 795,Autophagy 702675-74-9 C23H26IN7O2S Inhibitors Akt mTOR PI3K API