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Gefapixant

Gefapixant structure

CAS No.: 1015787-98-0

Chemical Name:: Gefapixant

Synonyms: Gefapixant;MK-7264;MK7264;MK 7264;CS-2846;EOS-6104;EOS-61047;RO-4926219;Gefapixant(AF-219;Gefapixant (MK-7264)

CBNumber:: CB42596673

Molecular Formula:: C14H19N5O4S

Molecular Weight:: 353.4

MDL Number:: MFCD24539325

MOL File:: 1015787-98-0.mol

Last updated:2024-11-19 23:02:33

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Gefapixant Properties

Boiling point	606.3±65.0 °C(Predicted)
Density	1.391±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:38.0(Max Conc. mg/mL);107.53(Max Conc. mM)
form	Solid
pka	9.90±0.60(Predicted)
color	White to off-white
FDA UNII	6K6L7E3F1L

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Gefapixant price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0021727	Gefapixant 99.62%	1015787-98-0	5mg	$110	2021-12-16	Buy
Biosynth Carbosynth	BM170818	MK 7264	1015787-98-0	10mg	$125	2021-12-16	Buy
ChemScene	CS-0021727	Gefapixant 99.62%	1015787-98-0	10mg	$160	2021-12-16	Buy
AK Scientific	8545BB	Gefapixant	1015787-98-0	10mg	$218	2021-12-16	Buy
ChemScene	CS-0021727	Gefapixant 99.62%	1015787-98-0	25mg	$320	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-0021727	5mg	$110	Buy
BM170818	10mg	$125	Buy
CS-0021727	10mg	$160	Buy
8545BB	10mg	$218	Buy
CS-0021727	25mg	$320	Buy

Gefapixant Chemical Properties,Uses,Production

Description

Gefapixant was approved in Japan in 2022 for adult patients with refractory or unexplained chronic cough, marketed under the name Lyfnua.The drug was authorised by the European Medicines Agency (EMA) in September 2023 for the same indication. However, the FDA refused to approve gefapixant for the treatment of adults with refractory or unexplained chronic cough.

Uses

Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis.

Gefapixant Preparation Products And Raw materials

Raw materials

2-ISOPROPYL-4-METHOXYPHENOL 2,4-Diaminopyrimidine Chlorosulfonic acid METHOXYPHENOL, PARA-(SG) Sulfamide

Preparation Products

Gefapixant Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418684 +8618949823763	sales@tnjchem.com	China	25356	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Shochem(Shanghai) Co.,Ltd	58
BOC Sciences	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
CR Corporation Limited	58
InvivoChem	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

View Lastest Price from Gefapixant manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Gefapixant 1015787-98-0	US $53.00-158.00 / mg		99.72%	10g	TargetMol Chemicals Inc.
	2020-01-09	5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide 1015787-98-0	US $9.80 / KG	1g	≥99%	100kg	Career Henan Chemical Co

Gefapixant
1015787-98-0
US $53.00-158.00 / mg
99.72%
TargetMol Chemicals Inc.

5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide
1015787-98-0
US $9.80 / KG
≥99%
Career Henan Chemical Co

5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide EOS-61047 EOS-6104 Gefapixant(AF-219,MK-7264) RO-4926219 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)Benzenesulfonamide Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)- GEFAPIXANT; MK-7264; MK 7264; MK7264; AF-219; AF219; AF 219; RO4926219; RO-4926219; RO 4926219; GEFAPIXANT;AF-219;MK-7264;AF 219;MK 7264;AF219;MK7264 MK 7264 MK7264 CS-2846 Gefapixant(AF-219 5-[(2,4-Diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide Gefapixant MK-7264 Gefapixant,AF-219,MK 7264,inhibit,MK7264,chronic cough,P2X3,knee osteoarthritis,Inhibitor,AF 219,P2X Receptor,P2XRs Gefapixant (MK-7264) 1015787-98-0 APIS