AS601245
- CAS No.
- 345987-15-7
- Chemical Name:
- AS601245
- Synonyms
- CS-1619;AS601245;AS601245.TFA;JNK Inhibitor V;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245
- CBNumber:
- CB42627340
- Molecular Formula:
- C20H16N6S
- Molecular Weight:
- 372.45
- MDL Number:
- MFCD07772196
- MOL File:
- 345987-15-7.mol
| Boiling point | 635.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.366±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO |
| pka | 5.32±0.10(Predicted) |
| form | White to yellow solid. |
| color | Light yellow to yellow |
| FDA UNII | Y9A2N9O85G |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
AS601245 price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 420129 | JNK Inhibitor V - CAS 345987-15-7 - Calbiochem | 345987-15-7 | 5MG | $245 | 2024-03-01 | Buy |
| Cayman Chemical | 17542 | JNK Inhibitor V ≥98% (sum of isomers) | 345987-15-7 | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 17542 | JNK Inhibitor V ≥98% (sum of isomers) | 345987-15-7 | 5mg | $149 | 2024-03-01 | Buy |
| Cayman Chemical | 17542 | JNK Inhibitor V ≥98% (sum of isomers) | 345987-15-7 | 10mg | $268 | 2024-03-01 | Buy |
| Cayman Chemical | 17542 | JNK Inhibitor V ≥98% (sum of isomers) | 345987-15-7 | 25mg | $535 | 2024-03-01 | Buy |
AS601245 Chemical Properties,Uses,Production
Uses
JNK Inhibitor V is an anti-inflammatory JNK inhibitor with neuroprotective properties. JNK Inhibitor V and Clofibrate (C586910) synergistically inhibit proliferation, induce apoptosis and differentiation via differential modulation of gene expression profile in human colon cancer cells.
Definition
ChEBI: 2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile is a member of benzothiazoles.
Biological Activity
recent evidence suggests activation of the c-jun nh2-terminal protein kinase (jnk) signal transduction pathway may play a role in ischemia-induced cell death. therefore, preventing the activation of jnk, or c-jun phosphorylation could be neuroprotective. as601245 is a c-jun nh2-terminal protein kinase inhibitor.
in vitro
as601245 demonstrated a nonspecific inhibition of the three jnk human isoforms. as601245 inhibits isolated hjnk3 in an atpcompetitive manner. selectivity of as601245 was tested against a large panel of kinases. it exhibited 10- to 20-fold selectivity over c-src, cdk2, and c-raf and more than 50- to 100-fold selectivity over a range of tyr- and ser/thr-protein kinases [1].
in vivo
as601245 administered i.p. provided significant protection against the delayed loss of hippocampal ca1 neurons in a gerbil model of transient global ischemia. this effect is mediated by jnk inhibition and thus by c-jun expression and phosphorylation. a significant neuroprotective effect of as601245 administered either by i.p. injection or as i.v. bolus followed by an i.v. infusion was also observed in rats after focal cerebral ischemia [1].
IC 50
150, 220, and 70 nm for hjnk1, hjnk2, and hjnk3, respectively
References
[1] carboni s, hiver a, szyndralewiez c, gaillard p, gotteland jp, vitte pa. as601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-jun nh2-terminal protein kinase inhibitor with neuroprotective properties. j pharmacol exp ther. 2004 jul;310(1):25-32. epub 2004 feb 26.
AS601245 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
View Lastest Price from AS601245 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/8bc99468-0952-462c-b2a2-9c76546d4ce8.jpg) |
2020-01-10 | 2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile
345987-15-7
|
US $9.80 / KG | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- 2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile
345987-15-7
- US $9.80 / KG
- ≥98%
- Career Henan Chemical Co