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AS601245

AS601245 structure

CAS No.: 345987-15-7

Chemical Name:: AS601245

Synonyms: CS-1619;AS601245;AS601245.TFA;JNK Inhibitor V;AS601245, JNK inhibitor;2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]-;alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile;2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile;2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile;colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245

CBNumber:: CB42627340

Molecular Formula:: C20H16N6S

Molecular Weight:: 372.45

MDL Number:: MFCD07772196

MOL File:: 345987-15-7.mol

Last updated:2024-11-19 20:33:22

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AS601245 Properties

Boiling point	635.6±65.0 °C(Predicted)
Density	1.366±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥14.25 mg/mL in DMSO
pka	5.32±0.10(Predicted)
form	White to yellow solid.
color	Light yellow to yellow
FDA UNII	Y9A2N9O85G

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

2922500090

NFPA 704

	0
3		0

AS601245 price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	420129	JNK Inhibitor V - CAS 345987-15-7 - Calbiochem	345987-15-7	5MG	$245	2024-03-01	Buy
Cayman Chemical	17542	JNK Inhibitor V ≥98% (sum of isomers)	345987-15-7	1mg	$56	2024-03-01	Buy
Cayman Chemical	17542	JNK Inhibitor V ≥98% (sum of isomers)	345987-15-7	5mg	$149	2024-03-01	Buy
Cayman Chemical	17542	JNK Inhibitor V ≥98% (sum of isomers)	345987-15-7	10mg	$268	2024-03-01	Buy
Cayman Chemical	17542	JNK Inhibitor V ≥98% (sum of isomers)	345987-15-7	25mg	$535	2024-03-01	Buy

Product number	Packaging	Price	Buy
420129	5MG	$245	Buy
17542	1mg	$56	Buy
17542	5mg	$149	Buy
17542	10mg	$268	Buy
17542	25mg	$535	Buy

AS601245 Chemical Properties,Uses,Production

Uses

JNK Inhibitor V is an anti-inflammatory JNK inhibitor with neuroprotective properties. JNK Inhibitor V and Clofibrate (C586910) synergistically inhibit proliferation, induce apoptosis and differentiation via differential modulation of gene expression profile in human colon cancer cells.

Definition

ChEBI: 2-(1,3-benzothiazol-2-yl)-2-[2-[2-(3-pyridinyl)ethylamino]-4-pyrimidinyl]acetonitrile is a member of benzothiazoles.

Biological Activity

recent evidence suggests activation of the c-jun nh2-terminal protein kinase (jnk) signal transduction pathway may play a role in ischemia-induced cell death. therefore, preventing the activation of jnk, or c-jun phosphorylation could be neuroprotective. as601245 is a c-jun nh2-terminal protein kinase inhibitor.

in vitro

as601245 demonstrated a nonspecific inhibition of the three jnk human isoforms. as601245 inhibits isolated hjnk3 in an atpcompetitive manner. selectivity of as601245 was tested against a large panel of kinases. it exhibited 10- to 20-fold selectivity over c-src, cdk2, and c-raf and more than 50- to 100-fold selectivity over a range of tyr- and ser/thr-protein kinases [1].

in vivo

as601245 administered i.p. provided significant protection against the delayed loss of hippocampal ca1 neurons in a gerbil model of transient global ischemia. this effect is mediated by jnk inhibition and thus by c-jun expression and phosphorylation. a significant neuroprotective effect of as601245 administered either by i.p. injection or as i.v. bolus followed by an i.v. infusion was also observed in rats after focal cerebral ischemia [1].

IC 50

150, 220, and 70 nm for hjnk1, hjnk2, and hjnk3, respectively

References

[1] carboni s, hiver a, szyndralewiez c, gaillard p, gotteland jp, vitte pa. as601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-jun nh2-terminal protein kinase inhibitor with neuroprotective properties. j pharmacol exp ther. 2004 jul;310(1):25-32. epub 2004 feb 26.

AS601245 Preparation Products And Raw materials

Raw materials

Preparation Products

AS601245 Suppliers

Global( 64)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
Haoyuan Chemexpress Co., Ltd.	61
Sigma-Aldrich	80
Shanghai EFE Biological Technology Co., Ltd.	58

View Lastest Price from AS601245 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	AS601245 345987-15-7	US $41.00-172.00 / mg		99.02%	10g	TargetMol Chemicals Inc.
	2020-01-10	2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile 345987-15-7	US $9.80 / KG	1KG	≥98%	20 tons	Career Henan Chemical Co

AS601245
345987-15-7
US $41.00-172.00 / mg
99.02%
TargetMol Chemicals Inc.

2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile
345987-15-7
US $9.80 / KG
≥98%
Career Henan Chemical Co

AS601245 Spectrum

AS601245(345987-15-7)¹HNMR

345987-15-7(AS601245)Related Search:

1,9-Pyrazoloanthrone N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

AS601245 AS601245.TFA JNK Inhibitor V alpha-[2-[[2-(3-Pyridinyl)ethyl]amino]-4-pyrimidinyl]-2-benzothiazoleacetonitrile 2-(Benzo[d]thiazol-2-yl)-2-(2-((2-(pyridin-3-yl)ethyl)amino)pyrimidin-4-yl)acetonitrile 2-Benzothiazoleacetonitrile, α-[2-[[2-(3-pyridinyl)ethyl]amino]-4-pyrimidinyl]- CS-1619 2-(1,3-benzothiazol-2-yl)-2-[2-(2-pyridin-3-ylethylamino)pyrimidin-4-yl]acetonitrile colon,Inhibitor,inhibit,AS-601245,TNF-α,cancer,JNK,cells,neuroprotective,AS601245,release,anti-Inflammatory,AS 601245 AS601245, JNK inhibitor 345987-15-7 Inhibitors