ChemicalBook >> CAS DataBase List >>BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- structure

CAS No.: 1054543-47-3

Chemical Name:: BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-

Synonyms: Apoptozole;CS-2225;Apoptozole（AZ）;APOPTOSIS ACTIVATOR VII;5-bis(trifluoroMethyl)phenyl]-4;Apoptozole，Apoptosis Activator VII;Apoptosis Activator VII, Apoptozole;6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1);5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-;Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem

CBNumber:: CB42627395

Molecular Formula:: C33H25F6N3O3

Molecular Weight:: 625.56

MDL Number:: MFCD19443178

MOL File:: 1054543-47-3.mol

MSDS File:: SDS

Last updated:2024-11-19 20:33:22

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BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Properties

Melting point	225-228°C
Boiling point	703.5±70.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form	White solid
pka	15.98±0.50(Predicted)
color	White
FDA UNII	WD0EH16QCD

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17675	Apoptozole ≥98%	1054543-47-3	5mg	$73	2024-03-01	Buy
Cayman Chemical	17675	Apoptozole ≥98%	1054543-47-3	10mg	$116	2024-03-01	Buy
Cayman Chemical	17675	Apoptozole ≥98%	1054543-47-3	25mg	$270	2024-03-01	Buy
Cayman Chemical	17675	Apoptozole ≥98%	1054543-47-3	50mg	$468	2024-03-01	Buy
TRC	A729045	Apoptozole	1054543-47-3	25mg	$1290	2021-12-16	Buy

Product number	Packaging	Price	Buy
17675	5mg	$73	Buy
17675	10mg	$116	Buy
17675	25mg	$270	Buy
17675	50mg	$468	Buy
A729045	25mg	$1290	Buy

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Chemical Properties,Uses,Production

Uses

Apoptozoleis an inhibitor of heat shock protein 70 (Hsp70) and acts by blocking its ATPase activity. Induces apoptosis in cancer cells.

General Description

A cell-permeable imidazole compound that directly binds anti-apoptotic chaperone Hsc70 and its inducible homologue Hsp70 (K_d = 210 and 140 nM, respectively). Apoptozole is shown to effectively inhibit the proliferation of SK-OV-3, HCT-15, and A549 cancer cell lines (IC₅₀ = 220, 250 and 130 nM, respectively) and induce 90% apoptotic cell death in P19 embryonic carcinoma and A549 lung cancer cultures after 12 h drug treatment (1 μM). Shown to suppress ubiquitination of mutant CFTR and promote membrane trafficking, and restore chloride channel activity.

Biological Activity

apoptozole is an inhibitor of atpase activity of hsp70 [1].the heat shock protein 70 (hsp70) protein family plays diverse roles in biological processes and has multiple functions involved in suppression of apoptotic pathways through multiple anti-apoptotic processes. the two major members, constitutive hsc70 and inducible hsp70, are composed of an n-terminal atpase domain and a c-terminal substrate binding domain [1][2].apoptozole (az) is an inhibitor of atpase activity of hsp70. apoptozole inhibited the atpase activity of hsp70 by binding to its atpase domain. in the presence of 200 μm atp, apoptozole inhibited the atpase activity of hsp70 by 32% and 65% at 100 μm and 200 μm, respectively. apoptozole bound hsp70 but not hsp40, hsp60, and hsp90. in several cancer cell lines, apoptozole induced apoptosis in a dose-dependent way with ic50 values ranged from 5 to 7 μm. in hela cells, apoptozole decreased the amount of apaf-1 associated with hsp70 without affecting the expression level of apaf-1, and produced cleaved procaspase-9, suggesting that apoptozole blocked association of hsp70 with apaf-1 and induced caspase-dependent apoptosis.in the nude mice xenografted with a549, rko (colorectal carcinoma), and hela cells, i.p injection of apoptozole reduced tumor volumes by 61%, 65%, and 68%, respectively [1]. in mice administered with both protein antigen and az, az increased immune responses to administered antigens and produced more antibodies [2].

References

[1]. ko sk, kim j, na dc, et al. a small molecule inhibitor of atpase activity of hsp70 induces apoptosis and has antitumor activities. chem biol. 2015 mar 19;22(3):391-403.
[2]. baek kh, zhang h, lee br, et al. a small molecule inhibitor for atpase activity of hsp70 and hsc70 enhances the immune response to protein antigens. sci rep. 2015 dec 3;5:17642.

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Suppliers

Global( 71)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32956	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30238	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	+86-519-85525359 +86-15995072465	sales@xuanmingchem.com	China	914	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58

View Lastest Price from BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	Apoptozole 1054543-47-3	US $30.00-76.00 / mg		98.02%	10g	TargetMol Chemicals Inc.

Apoptozole
1054543-47-3
US $30.00-76.00 / mg
98.02%
TargetMol Chemicals Inc.

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Spectrum

BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-(1054543-47-3)¹HNMR

1054543-47-3(BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]-)Related Search:

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BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Apoptosis Activator VII, Apoptozole 6-BROMO-4-CHLOROQUINOLINE HYDROCHLORIDE (1:1) 5-bis(trifluoroMethyl)phenyl]-4 5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- Apoptosis Activator VII, Apoptozole - CAS 1054543-47-3 - Calbiochem 4-({2-[3,5-Bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1 H-imidazol-1-yl}methyl)benzamide Apoptozole，Apoptosis Activator VII 4-((2-(3,5-bis(trifluoromethyl)phenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole-1-yl)methyl)benzamide APOPTOSIS ACTIVATOR VII CS-2225 Apoptozole domain,Heat shock proteins,inhibit,Inhibitor,Apoptosis,HSP,Hsp70,Apoptozole,ATPase,Hsc70 Apoptozole（AZ） 1054543-47-3 C33H25F6N3O3