CCT 244747
- CAS No.
- 1404095-34-6
- Chemical Name:
- CCT 244747
- Synonyms
- CS-1625;CCT 244747;CCT-244747; CCT 244747;CCT244747; CCT-244747; CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
- CBNumber:
- CB92668551
- Molecular Formula:
- C20H24N8O2
- Molecular Weight:
- 408.46
- MDL Number:
- MFCD25977017
- MOL File:
- 1404095-34-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H318 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P330-P305+P351+P338-P310-P501 | |||||||||
| NFPA 704 |
|
CCT 244747 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25666 | CCT244747 ≥98% | 1404095-34-6 | 1mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 25666 | CCT244747 ≥98% | 1404095-34-6 | 5mg | $207 | 2024-03-01 | Buy |
| Cayman Chemical | 25666 | CCT244747 ≥98% | 1404095-34-6 | 10mg | $341 | 2024-03-01 | Buy |
| Biosynth Carbosynth | FD145154 | 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile | 1404095-34-6 | 5mg | $390 | 2021-12-16 | Buy |
| ApexBio Technology | B5880 | CCT244747 | 1404095-34-6 | 10mg | $394 | 2021-12-16 | Buy |
CCT 244747 Chemical Properties,Uses,Production
Description
CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.
in vitro
cct244747 inhibited cellular chk1 activity, significantly enhanced the cytotoxicity of a few anticancer drugs and abrogated drug-induced s and g2 arrest in multiple tumor cell lines. biomarkers of chk1 activity and cell cycle inactivity were induced by genotoxics and inhibited by cct244747, producing enhanced dna damage and apoptosis [1].
in vivo
active tumor concentrations of cct244747 were obtained following oral administration. the antitumor activities of both gemcitabine and irinotecan were significantly enhanced by cct244747 in human tumor xenografts, giving concomitant biomarker modulation indicative of chk1 inhibition [1].
IC 50
29-170 nm
References
[1] walton mi, eve pd, hayes a, valenti mr, de haven brandon ak, box g, hallsworth a, smith el, boxall kj, lainchbury m, matthews tp, jamin y, robinson sp, aherne gw, reader jc, chesler l, raynaud fi, eccles sa, collins i, garrett md. cct244747 is a novel potent and selective chk1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs. clin cancer res. 2012 oct 15;18(20):5650-61.
CCT 244747 Preparation Products And Raw materials
Raw materials
Preparation Products
CCT 244747 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 2031 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |