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ChemicalBook >> CAS DataBase List >> CCT 244747

CCT 244747

CCT 244747 price.
  • $70 - $1181
  • Product name: CCT 244747
  • CAS: 1404095-34-6
  • MF: C20H24N8O2
  • MW: 408.46
  • EINECS:
  • MDL Number:MFCD25977017
  • Synonyms:CCT 244747;3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile;3-{[(2R)-1-(Dimethylamino)-2-propanyl]oxy}-5-{[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino}-2-pyrazinecarbonitrile;CCT244747; CCT-244747; CCT 244747;CS-1625;CCT-244747; CCT 244747;2-Pyrazinecarbonitrile, 3-[(1R)-2-(dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-
Price22 Properties Safety Information Description
22 prices
Selected condition：
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1216-M005
  • Product descriptionCCT244747 ≥95%
  • Packaging5mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2857DM
  • Product descriptionCID54758482
  • Packaging5mg
  • Price$326
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging2mg
  • Price$142
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging5mg
  • Price$236
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging10mg
  • Price$394
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging25mg
  • Price$709
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB5880
  • Product descriptionCCT244747
  • Packaging50mg
  • Price$1181
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging1mg
  • Price$134
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging2mg
  • Price$214
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging5mg
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging10mg
  • Price$620
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFD145154
  • Product description3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile
  • Packaging25mg
  • Price$1125
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number25666
  • Product descriptionCCT244747 ≥98%
  • Packaging1mg
  • Price$70
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25666
  • Product descriptionCCT244747 ≥98%
  • Packaging5mg
  • Price$207
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number25666
  • Product descriptionCCT244747 ≥98%
  • Packaging10mg
  • Price$341
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5919
  • Product descriptionCCT244747 >99.0%
  • Packaging2mg
  • Price$108
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1216-M005 CCT244747 ≥95% 5mg $205 2021-12-16 Buy
AK Scientific 2857DM CID54758482 5mg $326 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 2mg $142 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 5mg $236 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 10mg $394 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 25mg $709 2021-12-16 Buy
ApexBio Technology B5880 CCT244747 50mg $1181 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 1mg $134 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 2mg $214 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 5mg $390 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 10mg $620 2021-12-16 Buy
Biosynth Carbosynth FD145154 3-[(1R)-2-(Dimethylamino)-1-methylethoxy]-5-[[4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)-2-pyridinyl]amino]-2-pyrazinecarbonitrile 25mg $1125 2021-12-16 Buy
Cayman Chemical 25666 CCT244747 ≥98% 1mg $70 2024-03-01 Buy
Cayman Chemical 25666 CCT244747 ≥98% 5mg $207 2024-03-01 Buy
Cayman Chemical 25666 CCT244747 ≥98% 10mg $341 2024-03-01 Buy
ChemScene CS-5919 CCT244747 >99.0% 2mg $108 2021-12-16 Buy
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Properties

Boiling point :562.6±50.0 °C(Predicted)
Density :1.27±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :A solid
pka :8.15±0.28(Predicted)
color :Light yellow to yellow

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310 Immediately call a POISON CENTER or doctor/physician.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

CCT244747 is a potent inhibitor of checkpoint kinase 1 (Chk1; IC50 = 8 nM). It is selective for Chk1 over FLT3, Chk2, and CDK1 (IC50s = 600, >10,000, and >10,000 nM, respectively) as well as a panel of 121 additional kinases at a concentration of 10 μM. CCT244747 reverses cell cycle arrest at the G2/M phase induced by etoposide and SN-38 in HT-29 cells and gemcitabine (Item Nos. 11690 | 9003096) in SW620 cells, indicating cellular G2 checkpoint abrogation. It potentiates the genotoxicity of SN-38, gemcitabine, and etoposide in HT-29, SW620, MiaPaCa-2, and Calu-6 cells with potentiation index (PI) values ranging from 1.9-8.5, 2.6-12.2, 5-16, and 1.4-5.6, respectively. In vivo, CCT244747 (75 mg/kg), in combination with irinotecan or gemcitabine, increases the delay of tumor growth in SW620 and Calu-6 mouse xenograft models, respectively.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific Shanghai Boyle Chemical Co., Ltd. Haoyuan Chemexpress Co., Ltd. MedChemexpress LLC HangZhou YuHao Chemical Technology Co., Ltd. AdooQ Bioscience CHINA