2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
- CAS No.
- 105955-01-9
- Chemical Name:
- 2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
- Synonyms
- KS370G,KS-370G;KS 370G >=98% (HPLC);N-caffeoyl-2-phenylethylamine;2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)-
- CBNumber:
- CB42639130
- Molecular Formula:
- C17H17NO3
- Molecular Weight:
- 283.32
- MDL Number:
- MOL File:
- 105955-01-9.mol
2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Chemical Properties,Uses,Production
Description
KS370G is an inhibitor of UUO-induced renal fibrosis markers expression. It acts by attenuating collagen deposition in the obstructed kidney and significantly lowering the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker.
in vitro
KS370G significantly inhibited the release of nitric oxide (NO) and the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Treatment with KS370G also induced heme oxygenase (HO)-1 and suppressors of cytokine signaling (SOCS)-3 expression in the microglia._x000D_ _x000D_ Reference: Mol Neurobiol. 2013 Dec;48(3):863-74. https://pubmed.ncbi.nlm.nih.gov/23801310/
in vivo
The results show that KS370G significantly attenuated collagen deposition in the obstructed murine kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). KS370G significantly lowered the expression of renal inflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b)._x000D_ _x000D_ Reference: Eur J Pharmacol. 2015 Mar 5;750:1-7. https://pubmed.ncbi.nlm.nih.gov/25620133/
target
KS370G is an inhibitor of UUO-induced renal fibrosis markers expression.
2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
2-PropenaMide, 3-(3,4-dihydroxyphenyl)-N-(2-phenylethyl)- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10269 | 58 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9874 | 58 |
Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Supplier | Advantage |
---|---|
ATK CHEMICAL COMPANY LIMITED | 60 |
TargetMol Chemicals Inc. | 58 |
Hangzhou Sage Chemical Co., Ltd. | 58 |
Shanghai Chaolan Chemical Technology Center | 58 |
Energy Chemical | 58 |
TargetMol Chemicals Inc. | 58 |