ChemicalBook >> CAS DataBase List >>Sarecycline Hydrochloride
Sarecycline Hydrochloride
- CAS No.
- 1035979-44-2
- Chemical Name:
- Sarecycline Hydrochloride
- Synonyms
- Sarecycline;Sarecycline HCl;P005672;P005672 HCl;P005672 (hydrochloride);CS-267;PO05672;PO05672 HCl;P0-05672;P0 05672;Sarecycline(P005672)
- CBNumber:
- CB42648136
- Molecular Formula:
- C24H30ClN3O8
- Molecular Weight:
- 523.97
- MDL Number:
- MFCD24444565
- MOL File:
- 1035979-44-2.mol
- MSDS File:
- SDS
Last updated:2025-04-17 18:22:24
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMF: 0.25 mg/ml,DMSO: 0.25 mg/ml |
| form | Solid |
| color | Light yellow to yellow |
| FDA UNII | 36718856JR |
| ATC code | J01AA14 |
| UNSPSC Code | 51101500 |
Sarecycline Hydrochloride price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 24685 | P005672 (hydrochloride) ≥98% | 1035979-44-2 | 1mg | $43 | 2023-01-06 | Buy |
| Cayman Chemical | 24685 | P005672 (hydrochloride) ≥98% | 1035979-44-2 | 5mg | $191 | 2023-01-06 | Buy |
| Cayman Chemical | 24685 | P005672 (hydrochloride) ≥98% | 1035979-44-2 | 10mg | $359 | 2023-01-06 | Buy |
| Cayman Chemical | 24685 | P005672 (hydrochloride) ≥98% | 1035979-44-2 | 25mg | $739 | 2023-01-06 | Buy |
| TRC | S140525 | SarecyclineHydrochloride | 1035979-44-2 | 50mg | $1575 | 2021-12-16 | Buy |
Sarecycline Hydrochloride Chemical Properties,Uses,Production
Uses
Sarecycline Hydrochloride is a substituted tetracycline compound used for treatment of bacterial infections and neoplasms.
Biological Activity
Sarecycline Hydrochloride iinhibits bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome. Specifically, it binds to the A site of the ribosome and blocks the attachment of aminoacyl-tRNA molecules to the ribosome, which is necessary for the addition of new amino acids to the growing polypeptide chain. This ultimately leads to the inhibition of bacterial protein synthesis and reduction in bacteria th at are associated with acne.
in vivo
Sarecycline hydrochloride (0.33-9? mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model[1].
Sarecycline can inhibit S. aureus (PD50=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model[6].
| Animal Model: | Female SD-1 mice (A murine neutropenic thigh wound infection model)[1] |
| Dosage: | 0.33, 1, 3, or 9?mg/kg |
| Administration: | Intravenously |
| Result: | Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively. |
| Animal Model: | Carrageenan-induced footpad edema male Sprague Dawley rats model[6] |
| Dosage: | 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg |
| Administration: | Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. |
| Result: | Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline. |
IC 50
Tetracycline
Sarecycline Hydrochloride Preparation Products And Raw materials
Global( 103)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29808 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Changzhou Xuanming Pharmaceutical Technology Co., Ltd. | +86-519-85525359 +86-15995072465 | sales@xuanmingchem.com | China | 914 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3148 | 58 |
Related articles
- The Synthetic method and Drug interaction of Sarecycline
- Sarecycline Hydrochloride is the hydrochloride form of sarecycline. Sarecycline is a novel tetracycline-derived drug, specific....
- Dec 20，2023
View Lastest Price from Sarecycline Hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-03-04 | Minocycline Impurity 14 | US $0.00-0.00 / mg | 10mg | 0.98 | 5g | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2024-08-05 | Sarecycline Hydrochloride
1035979-44-2
|
US $0.10 / KG | 1KG | 99.0% | 1000Tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-20 | P005672 hydrochloride
1035979-44-2
|
US $1.00 / KG | 1KG | 99% | 100kgs | Career Henan Chemical Co |
-
- Minocycline Impurity 14
- US $0.00-0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Sarecycline Hydrochloride
1035979-44-2
- US $0.10 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- P005672 hydrochloride
1035979-44-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
1035979-44-2(Sarecycline Hydrochloride)Related Search:
Amicycline
Sancycline hydrochloride
9-Monodemethyl Minocycline
DISCONTINUED
YRJLVLGBPUKKRD-YXALHFAPSA-N
7-Didemethyl Minocycline Dihydrochloride (>85% by HPLC)
4-Chloro-2,6-diaminopyrimidine
4-Epiminocycline
Minocycline hydrochloride
Tigecycline Metabolite M6 (9-AniMoMinocycline)
2,4-DIAMINO-6-PIPERIDINOPYRIMIDINE
1of4
(4S,4aS,5aR,12aS)-4-(DiMethylaMino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(MethoxyMethylaMino)Methyl]-1,11-dioxo-2-naphthacenecarboxaMide hydrochloride
Sarecycline (hydrochloride)
4S,4aS,5aR,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-7-[(methoxymethylamino)methyl]-1,11-dioxo-2-naphthacenecarboxamide hydrochloride P005672 HCl
(4S,4AS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-
P005672 HCl (Sarecycline HCl)
PO05672 HCl
Minocycline Impurity 14
CS-267
Sarecycline(P005672)
P005672(SARECYCLINE HCL)
(4S,4aS,5aR,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide,hydrochloride
P0-05672;P0 05672
Minocycline Impurity 14（Sarecycline）
PO05672
PO05672;SARECYCLINE HCL
Sarecycline(P005672 hydrochloride)
(4s,4as,5ar,12ar)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-7-[[methoxy(methyl)amino]methyl]-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide
P005672 HCl
P005672 (hydrochloride)
Sarecycline
Sarecycline HCl
P005672
Phenol,3,6-dimethoxy-
13C,2H3]-Sarecycline hydrochloride
(4S,4aS,5aR,12aS)-4-(Dimethylamino)-3,10,12,12a-tetrahydroxy-7-((methoxy(methyl)amino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrochloride
Sarecycline (P005672 HCl)
1035979-44-2
C24H29N3O8HCl