ChemicalBook >> CAS DataBase List >>Minoxidil sulphate
Minoxidil sulphate
- CAS No.
- 83701-22-8
- Chemical Name:
- Minoxidil sulphate
- Synonyms
- U-58838;MINOXIDIL SULFATE;MINOXIDIL SULPHATE;Minoxidil O-sulfate;minoxidilsulfateester;Minoxidil Sulphate INH;Sulfuric acid minoxidil;MINOXIDIL SUFATE ETHYLATED;Ketotifen Fumarate Tablets;Minoxidil sulfate (U-58838)
- CBNumber:
- CB9494019
- Molecular Formula:
- C9H15N5O4S
- Molecular Weight:
- 289.31
- MDL Number:
- MFCD06248907
- MOL File:
- 83701-22-8.mol
- MSDS File:
- SDS
Last updated:2024-10-31 18:15:48
| Melting point | 175-180°C |
|---|---|
| Density | 1.75±0.1 g/cm3(Predicted) |
| RTECS | UV6260494 |
| storage temp. | -20°C |
| solubility | Acetone (Slightly), DMSO (Slightly) |
| form | White solid. |
| pka | -4.99±0.18(Predicted) |
| color | White to Off-White |
| Stability | Light Sensitive - Protect from Light, Store in Freezer |
| InChI | InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17) |
| InChIKey | AGMYAAIWWVATKU-UHFFFAOYSA-N |
| SMILES | C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1 |
| CAS DataBase Reference | 83701-22-8(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2H6K6Y231J |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335-H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338-P301+P312+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T+ | |||||||||
| Risk Statements | 22-36/37/38-26/27/28 | |||||||||
| Safety Statements | 26-36-45-36/37/39-22 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
Minoxidil sulphate price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M7920 | Minoxidil sulfate salt | 83701-22-8 | 1mg | $42.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | M7920 | Minoxidil sulfate salt | 83701-22-8 | 5mg | $195 | 2024-03-01 | Buy |
| Alfa Aesar | J67021 | Minoxidil sulfate, 98% | 83701-22-8 | 5mg | $128 | 2021-12-16 | Buy |
| TRC | M345100 | MinoxidilSulfate | 83701-22-8 | 25mg | $145 | 2021-12-16 | Buy |
| TRC | M345100 | MinoxidilSulfate | 83701-22-8 | 50mg | $275 | 2021-12-16 | Buy |
Minoxidil sulphate Chemical Properties,Uses,Production
Application
Minoxidil sulfate was the drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp. The water solubility characteristics of minoxidil sulfate increases the absorption.
Before that, minoxidil sulfate had been used as vasodilator drug prescribed as an oral tablet to treat high blood pressure and it’s can used for refractory hypertension and renal hypertension. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.
Chemical Properties
White Crystalline Solid
Uses
Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.
Uses
specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite
Uses
A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant
Biological Functions
Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.
Biochem/physiol Actions
Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.
in vitro
Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Minoxidil sulphate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 283)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Golt Biotech Co., Ltd. | +8615389281203 | maria@goltbiotech.com | China | 970 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12837 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5986 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Hong Kong Excellence Biotechnology Co., Ltd. | ada@sh-teruiop.com | China | 875 | 58 | |
| Anhui Yiao New Material Technology Co., Ltd | +86-18033737140 +86-17354101231 | sales1@hbganmiao.com | China | 227 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Sigma Audley | +86-15937194204 +86-18126314766 | nova@sh-teruiop.com | China | 493 | 58 |
| airuikechemical co., ltd. | +undefined86-15315557071 | sales02@sdzhonghuimaterial.com | China | 983 | 58 |
| Shanghai Aosiris new Material Technology Co., LTD | 86-15139564871 +8615139564871 | wrjmoon2000@163.com | China | 109 | 58 |
Related articles
- Minoxidil sulphate: History and Pharmacokinetics
- Minoxidil sulphate, approved for hypertension, later found use in treating baldness due to hypertrichosis. Its absorption and ....
- Mar 28，2024
- Minoxidil sulphate: origin, mechanism of action and applications
- Minoxidil sulphate is a commonly used treatment for hair loss, promoting hair regrowth and reducing hair loss.
- Oct 17，2023
- What is Minoxidil sulphate?
- Minoxidil sulfate was the drug approved by the FDA for the treatment of androgenetic alopecia (hair loss).Before that, minoxid....
- Feb 17，2020
View Lastest Price from Minoxidil sulphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-03 | Minoxidil sulphate
83701-22-8
|
US $1000.00-800.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-11-02 | Minoxidil sulphate
83701-22-8
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%min | 1000 KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-10-31 | Minoxidil sulphate
83701-22-8
|
US $3.00-1.00 / kg | 1kg | 99.9% | 10 tons | Shanghai Aosiris new Material Technology Co., LTD |
-
- Minoxidil sulphate
83701-22-8
- US $1000.00-800.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Minoxidil sulphate
83701-22-8
- US $0.00-0.00 / Kg/Drum
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Minoxidil sulphate
83701-22-8
- US $3.00-1.00 / kg
- 99.9%
- Shanghai Aosiris new Material Technology Co., LTD
83701-22-8(Minoxidil sulphate)Related Search:
1of4
Sulfuric acid minoxidil
Minoxidil sulfate (U-58838)
6-(1-PIPERIDINYL)-2,4-PYRIMIDINEDIAMINE-3-OXIDE SULFATE
MINOXIDIL SULFATE
MINOXIDIL SULPHATE
U-58838
MINOXIDIL SUFATE ETHYLATED
1,6-Dihydro-6-iMino-4-(1-piperidinyl)-1-(sulfooxy)-
1,6-Dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-2-pyrimidinamine
Minoxidil O-sulfate
2-Pyrimidinamine, 1,6-dihydro-6-imino-4-(1-piperidinyl)-1-(sulfooxy)-
minoxidilsulfateester
2,6-Diamino-4-(piperidin-1-yl)-pyrimidine 1-oxide sulfate
(Z)-2,2,2-trifluoro-1-(3-fluoropyridin-2-yl)ethanone oxiMe
Ketotifen Fumarate Tablets
Minoxidil sulphate USP/EP/BP
Minoxidil sulphateQ: What is
Minoxidil sulphate Q: What is the CAS Number of
Minoxidil sulphate Q: What is the storage condition of
Minoxidil sulphate
Minoxidil Sulphate INH
83701-22-8
883701-22-8
C9H15N5O4S
C9H15N5OSO3
C9H17N5O5S
Voltage-gated Ion Channels
Potassium Channel Modulators
Ion Channels
Monovalent Ion Channels
BioChemical
Cell Biology
Cell Signaling and Neuroscience
Other APIs
Various Metabolites and Impurities
Intermediates & Fine Chemicals
Metabolites
Pharmaceuticals
APIs