ChemicalBook >> CAS DataBase List >>GSK-1605786
GSK-1605786
- CAS No.
- 698394-73-9
- Chemical Name:
- GSK-1605786
- Synonyms
- CCX282-B;Vercirnon;GSK1605786;Traficet-EN;GSK-1605786;GSK 1605786;Vercirnon GSK1605786;4-(2-(4-tert-butylphenylsulfonamido)-5-chlorobenzoyl)pyridin-1(2H)-olate;4-(2-((4-(tert-Butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide;N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-benzenesulfonamide
- CBNumber:
- CB42668435
- Molecular Formula:
- C22H21ClN2O4S
- Molecular Weight:
- 444.93
- MDL Number:
- MOL File:
- 698394-73-9.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:08
| Boiling point | 672.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.29±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 25 mg/ml |
| form | A crystalline solid |
| pka | 7.07±0.10(Predicted) |
| color | White to off-white |
| FDA UNII | MWI54OUA12 |
GSK-1605786 price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 23131 | Vercirnon | 698394-73-9 | 1mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 23131 | Vercirnon | 698394-73-9 | 5mg | $377 | 2024-03-01 | Buy |
| ChemScene | CS-4963 | Vercirnon 98.19% | 698394-73-9 | 5mg | $420 | 2021-12-16 | Buy |
| AK Scientific | 6855CR | Vercirnon | 698394-73-9 | 5mg | $517 | 2021-12-16 | Buy |
| ChemScene | CS-4963 | Vercirnon 98.19% | 698394-73-9 | 10mg | $600 | 2021-12-16 | Buy |
GSK-1605786 Chemical Properties,Uses,Production
Description
Vercirnon is an orally bioavailable antagonist of chemokine receptor 9 (CCR9) with an IC50 value of 5.4 nM for inhibition of CCL25-induced calcium mobilization in Molt-4 cells. It is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s = >10 μM for all). It also inhibits CCL25-induced Molt-4 chemotaxis in 0.1% BSA/HBSS and in 100% human AB serum (IC50s = 3.5 and 33.4 nM, respectively), as well as chemotaxis of human T cells stimulated by retinoic acid (RA) and mouse and rat thymocytes. Vercirnon binds allosterically to the intracellular side of CCR9 and prevents G protein coupling.
GSK-1605786 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK-1605786 Suppliers
Global( 30)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29820 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 4424 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29786 | 68 |
698394-73-9(GSK-1605786)Related Search:
GSK 1605786
GSK1605786
GSK-1605786
Vercirnon
Vercirnon GSK1605786
4-(2-(4-tert-butylphenylsulfonamido)-5-chlorobenzoyl)pyridin-1(2H)-olate
Benzenesulfonamide, N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-
CCX282-B
Traficet-EN
chemotaxis,CCR,bioavailable,Vercirnon,oral,GSK 1605786,inhibit,inflammatory,Inhibitor,bowel,GSK1605786,chemokine,CC chemokine receptor,disease
4-(2-((4-(tert-Butyl)phenyl)sulfonamido)-5-chlorobenzoyl)pyridine 1-oxide
N-[4-chloro-2-[(1-oxido-4-pyridinyl)carbonyl]phenyl]-4-(1,1-dimethylethyl)-benzenesulfonamide
698394-73-9