Mps1-IN-2
- CAS No.
- 1228817-38-6
- Chemical Name:
- Mps1-IN-2
- Synonyms
- CS-1837;Mps1-IN-2;Msp1-IN-2;Mps1 inhibitor 2;Mps1-IN-2 >=98% (HPLC);inhibit,Inhibitor,Monopolar spindle 1,Mps1,Mps1 IN 2,Polo-like Kinase (PLK),Mps1IN2,Mps-1-IN-2;9-cyclopentyl-2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5-methyl-5H,6H,7H,8H,9H-pyrimido[4,5-b][1,4]diazepin-6-one;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one;6H-Pyrimido[4,5-b][1,4]diazepin-6-one, 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-;9-Cyclopentyl-2-[[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino]-5-methyl-8,9-dihydro-5H-pyrimido[4,5-b][1,4]diazepin-6(7H)-one Mps1-in-2
- CBNumber:
- CB42682015
- Molecular Formula:
- C26H36N6O3
- Molecular Weight:
- 480.6
- MDL Number:
- MFCD28167735
- MOL File:
- 1228817-38-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Mps1-IN-2 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19401 | Mps1-IN-2 | 1228817-38-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19401 | Mps1-IN-2 | 1228817-38-6 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 19401 | Mps1-IN-2 | 1228817-38-6 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 19401 | Mps1-IN-2 | 1228817-38-6 | 25mg | $456 | 2024-03-01 | Buy |
| TRC | M745848 | Mps1-IN-2 | 1228817-38-6 | 5mg | $150 | 2021-12-16 | Buy |
Mps1-IN-2 Chemical Properties,Uses,Production
Uses
Mps1-IN-2 is a novel Mps1 inhibitor.
Definition
ChEBI: Mps1-IN-2 is a member of piperidines.
Biological Activity
mps1-in-2 is a potent and selective atp-competitive inhibitor of mps1 kinase with the ic50 value of 145nm [1].mps1-in-2 has been reported to inhibit mps1 kinase activity with the ic50 value of 145nm, when screened at 1μm atp. in addition, mps1-in-2 has shown greater than 1000-fold selectivity to the alk and ltk enzyme. moreover, mps1-in-2 has been revealed to bound to the atp biding pocket of mpa1 and formed a hydrogen bond with the hinge backbone (glu603) at 2.74-å resolution. mps1-in-2 has been noted to abrogate sac function and override the checkpoint through direct inhibition of mps1[1].
References
[1] kwiatkowski n1, jelluma n, filippakopoulos p, soundararajan m, manak ms, kwon m, choi hg, sim t, deveraux ql, rottmann s, pellman d, shah jv, kops gj, knapp s, gray ns. small-molecule kinase inhibitors provide insight into mps1 cell cycle function. nat chem biol. 2010 may;6(5):359-68. doi: 10.1038/nchembio.345. epub 2010 apr 11.
Mps1-IN-2 Preparation Products And Raw materials
Raw materials
Preparation Products
Mps1-IN-2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
