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(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide

CAS No.
1378872-36-6
Chemical Name:
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
Synonyms
ML239;CID49843203;CID 49843203;CID-49843203;CID-49843203;ML 239;NVEDPFICKAIHKD-NGYBGAFCSA-N;inhibit,ML239,ML-239,Inhibitor,ML 239;CID-49843203;CID 49843203;CID49843203;ML-239;ML 239;ML239;1378872-36-6;(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide;N'-[(E)-1H-Pyrrol-2-ylmethylene]-2-(2,4,6-trichlorophenoxy)acetoh ydrazide
CBNumber:
CB42751058
Molecular Formula:
C13H10Cl3N3O2
Molecular Weight:
346.6
MDL Number:
MFCD23098913
MOL File:
1378872-36-6.mol
Last updated:2024-11-19 23:02:33

(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,2-8°C
solubility DMSO: soluble15mg/mL (clear solution)
pka 11.95±0.46(Predicted)
form powder
color white to beige
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20° for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H400
Precautionary statements  P273-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  26
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
NFPA 704
0
3 0

(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0442 ML239 ≥98% (HPLC) 1378872-36-6 5mg $103 2024-03-01 Buy
Sigma-Aldrich SML0442 ML239 ≥98% (HPLC) 1378872-36-6 25mg $440 2022-05-15 Buy
Cayman Chemical 15188 ML-239 ≥98% 1378872-36-6 1mg $32 2024-03-01 Buy
Cayman Chemical 15188 ML-239 ≥98% 1378872-36-6 5mg $81 2024-03-01 Buy
Cayman Chemical 15188 ML-239 ≥98% 1378872-36-6 10mg $153 2024-03-01 Buy
Product number Packaging Price Buy
SML0442 5mg $103 Buy
SML0442 25mg $440 Buy
15188 1mg $32 Buy
15188 5mg $81 Buy
15188 10mg $153 Buy

(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Chemical Properties,Uses,Production

Description

ML-239 is an inhibitor of cancer stem cells, displaying greater than 23-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 1.18 μM) over an isogenic control cell line (EC50 = 27.6 μM). It is also toxic to the breast carcinoma cell line MDA-MB-231. ML-239 alters the expression of genes in the MAPK, NF-κB, and inflammatory cytokine pathways. It is stable in saline and modestly stable in human plasma.

Uses

ML-239, is an inhibitor of breast cancer stem cells, with greater than 23 fold selectivity of inhibition in the cell line.

Definition

ChEBI: N'-(2-pyrrolylidenemethyl)-2-(2,4,6-trichlorophenoxy)acetohydrazide is an aromatic ether.

storage

Store at +4°C

References

1) Carmody et al. (2012), Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells; J. Biomol. Screening, 17 1204 2) Germain et al. (2012), Identification of a selective small molecule inhibitor of breast cancer stem cells; Bioorg. Med. Chem., 22 3571 3) Rees et al. (2015), Correlating chemical sensitivity and basal gene expression reveals mechanism of action; Nat. Chem. Biol. 12 109

(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30240 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38632 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4512 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8011 62

View Lastest Price from (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ML239 pictures 2024-11-19 ML239
1378872-36-6
US $43.00-167.00 / mg 99.82% 10g TargetMol Chemicals Inc.
  • ML239 pictures
  • ML239
    1378872-36-6
  • US $43.00-167.00 / mg
  • 99.82%
  • TargetMol Chemicals Inc.
(2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide ML239 NVEDPFICKAIHKD-NGYBGAFCSA-N ML239【(E)-N'-((1H-pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide】 CID 49843203 CID49843203 CID-49843203 CID-49843203;CID 49843203;CID49843203;ML-239;ML 239;ML239;1378872-36-6 (E)-N'-((1H-pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide 2-(2,4,6-Trichlorophenoxy)acetic acid (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide CID-49843203;ML 239 N'-[(E)-1H-Pyrrol-2-ylmethylene]-2-(2,4,6-trichlorophenoxy)acetoh ydrazide Acetic acid, 2-(2,4,6-trichlorophenoxy)-, (2E)-2-(1H-pyrrol-2-ylmethylene)hydrazide inhibit,ML239,ML-239,Inhibitor,ML 239 (E)-N'-((1H-Pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide 1378872-36-6