ChemicalBook >> CAS DataBase List >>ML385
ML385
- CAS No.
- 846557-71-9
- Chemical Name:
- ML385
- Synonyms
- ML38;ML385;CS-2542;ML 385; ML-385;Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385;N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide;1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-;2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
- CBNumber:
- CB93168748
- Molecular Formula:
- C29H25N3O4S
- Molecular Weight:
- 511.59
- MDL Number:
- MFCD06616124
- MOL File:
- 846557-71-9.mol
- MSDS File:
- SDS
Last updated:2024-05-16 15:51:48
Density | 1.374±0.06 g/cm3(Predicted) |
---|---|
storage temp. | 2-8°C |
solubility |
DMSO:31.4(Max Conc. mg/mL);61.38(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);58.64(Max Conc. mM) DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.49(Max Conc. mM) |
form | powder |
pka | 8.92±0.50(Predicted) |
color | white to beige |
InChIKey | LINHYWKZVCNAMQ-UHFFFAOYSA-N |
SMILES | O1C2=CC=C(CC(NC3=NC(C4C=CC5=C(C=4)CCN5C(=O)C4=CC=CC=C4C)=C(C)S3)=O)C=C2OC1 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
ML385 price More Price(25)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1833 | ML385 ≥98% (HPLC) | 846557-71-9 | 5MG | $107 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1833 | ML385 ≥98% (HPLC) | 846557-71-9 | 25MG | $434 | 2023-06-20 | Buy |
Cayman Chemical | 21114 | ML-385 ≥98% | 846557-71-9 | 5mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 21114 | ML-385 ≥98% | 846557-71-9 | 10mg | $176 | 2024-03-01 | Buy |
Cayman Chemical | 21114 | ML-385 ≥98% | 846557-71-9 | 25mg | $388 | 2024-03-01 | Buy |
ML385 Chemical Properties,Uses,Production
Biochem/physiol Actions
ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.
storage
Store at -20°C
ML385 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 93)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
846557-71-9(ML385)Related Search:
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1of4
ML385
CS-2542
ML 385; ML-385
N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide
2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide
1,3-Benzodioxole-5-acetamide, N-[4-[2,3-dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-
Ferroptosis,ML385,Inhibitor,inhibit,ML-385,Keap1-Nrf2,ML 385
ML38
846557-71-9
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