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N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine

CAS No.
381168-77-0
Chemical Name:
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
Synonyms
ML367;ML-367,ML367,inhibit,ML 367,Inhibitor;N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine;4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)-
CBNumber:
CB04248334
Molecular Formula:
C19H12F2N4
Molecular Weight:
334.32
MDL Number:
MOL File:
381168-77-0.mol
Last updated:2024-11-12 15:22:20

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Properties

storage temp. Store at -20°C
solubility DMSO: ≥ 125 mg/mL (373.89 mM)
form Solid
color Light yellow to yellow

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Axon Medchem Axon2995 ML367-CID921541 99% 381168-77-0 10mg $137.5 2021-12-16 Buy
American Custom Chemicals Corporation HCH0275430 N-(3,4-DIFLUOROPHENYL)-2-PYRIDIN-4-YLQUINAZOLIN-4-AMINE 95.00% 381168-77-0 5MG $503.57 2021-12-16 Buy
DC Chemicals DC26162 ML367 >98% 381168-77-0 100mg $650 2021-12-16 Buy
DC Chemicals DC26162 ML367 >98% 381168-77-0 1g $2200 2021-12-16 Buy
Product number Packaging Price Buy
Axon2995 10mg $137.5 Buy
HCH0275430 5MG $503.57 Buy
DC26162 100mg $650 Buy
DC26162 1g $2200 Buy

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Chemical Properties,Uses,Production

Biological Activity

ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1.

in vitro

ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd.

Western Blot Analysis

< table class="zh_use_1"> Cell Line: HEK293T cells Concentration: 0-40 μM in the presence or absence of 20 μM 5-Furd Incubation Time: 16 hours Result: Inhibited the increased ATAD5 protein levels induced by 5-Furd.

target

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine Suppliers

Global( 25)Suppliers
TargetValue
ATAD5
()
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32957 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696,15000506266 15000506266 China 4566 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8012 62
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 9952 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29785 68

View Lastest Price from N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ML367 pictures 2024-11-12 ML367
381168-77-0
US $40.00-129.00 / mg 99.39% 10g TargetMol Chemicals Inc.
  • ML367 pictures
  • ML367
    381168-77-0
  • US $40.00-129.00 / mg
  • 99.39%
  • TargetMol Chemicals Inc.
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML367 4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)- ML-367,ML367,inhibit,ML 367,Inhibitor 381168-77-0 C19H12F2N4