Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Wee1 Inhibitor

Wee1 Inhibitor

Wee1 Inhibitor Structure
Wee1 Inhibitor structure
CAS No.
622855-37-2
Chemical Name:
Wee1 Inhibitor
Synonyms
WEE1-IN-4;Wee1 Inhibitor;WEE-1-IN-4,WEE1 IN 4,WEE1IN4;4-(2-chlorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione;Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2-chlorophenyl)-9-hydroxy-
CBNumber:
CB43036958
Molecular Formula:
C20H11ClN2O3
Molecular Weight:
362.77
MDL Number:
MOL File:
622855-37-2.mol
Last updated:2024-07-02 08:55:08
Request For Quotation

Wee1 Inhibitor Properties

storage temp. -20°C
solubility DMSO: 10 mg/ml,Ethanol: 10 mg/ml
form A solid
color Yellow to orange

Wee1 Inhibitor Chemical Properties,Uses,Production

Biological Activity

Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 μM for the E. coli enzyme).2

References

1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)

Wee1 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

Wee1 Inhibitor Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1249 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 10010 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4579 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Henan Alpha Chemical Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Wee1 Inhibitor Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2-chlorophenyl)-9-hydroxy- WEE1-IN-4 WEE-1-IN-4,WEE1 IN 4,WEE1IN4 4-(2-chlorophenyl)-9-hydroxy-6H-pyrrolo[3,4-c]carbazole-1,3-dione 622855-37-2 C20H11ClN2O3