Ixazomib citrate
- CAS No.
- 1239908-20-3
- Chemical Name:
- Ixazomib citrate
- Synonyms
- (R)-2,2'-(2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid;lxazomib;MLN9708（b）;Ixazomib citrat;Esazomib citrate;Lxazomib Citrate;Ixazomib-prodrug;Ixazomib Citrate;Ixazomibe citrate;S-Ixazomib citrate
- CBNumber:
- CB43067499
- Molecular Formula:
- C20H23BCl2N2O9
- Molecular Weight:
- 517.12
- MDL Number:
- MFCD29767859
- MOL File:
- 1239908-20-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Ixazomibcitrate[MLN9708] ≥95%(1H-NMR) | AG-CR1-3671-M001 | 1mg | $35 |
| Ixazomibcitrate 99.80% | CS-1720 | 5mg | $50 |
| Ixazomibcitrate 99.80% | CS-1720 | 10mg | $70 |
| Ixazomibcitrate[MLN9708] ≥95%(1H-NMR) | AG-CR1-3671-M005 | 5mg | $105 |
| Ixazomibcitrate 99.80% | CS-1720 | 50mg | $150 |
| More product size | |||
| Density | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMSO:100.0(Max Conc. mg/mL);193.38(Max Conc. mM) Ethanol:100.0(Max Conc. mg/mL);193.38(Max Conc. mM) |
| pka | 3.59±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| InChIKey | MBOMYENWWXQSNW-AWEZNQCLSA-N |
| SMILES | O1C(=O)C(CC(O)=O)(CC(O)=O)OB1[C@@H](NC(CNC(=O)C1=CC(Cl)=CC=C1Cl)=O)CC(C)C |
| FDA UNII | 46CWK97Z3K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360-H362 |
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313 |
Ixazomib citrate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3671-M001 | Ixazomibcitrate[MLN9708] ≥95%(1H-NMR) | 1239908-20-3 | 1mg | $35 | 2021-12-16 | Buy |
| ChemScene | CS-1720 | Ixazomibcitrate 99.80% | 1239908-20-3 | 5mg | $50 | 2021-12-16 | Buy |
| ChemScene | CS-1720 | Ixazomibcitrate 99.80% | 1239908-20-3 | 10mg | $70 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3671-M005 | Ixazomibcitrate[MLN9708] ≥95%(1H-NMR) | 1239908-20-3 | 5mg | $105 | 2021-12-16 | Buy |
| ChemScene | CS-1720 | Ixazomibcitrate 99.80% | 1239908-20-3 | 50mg | $150 | 2021-12-16 | Buy |
Ixazomib citrate Chemical Properties,Uses,Production
Uses
Ixazomib Citrate is a reversible boronic acid proteasome inhibitor.
Definition
ChEBI: A glycine derivative that is the amide obtained by formal condensation of the carboxy group of N-(2,5-dichlorobenzoyl)glycine with the amino group of 2,2'-{2-[(1R)-1-amino-3-methylbutyl]-5-oxo-1,3,2-dioxaborolane-4,4-diy }diacetic acid. A prodrug for ixazomib that is used in combination therapy for treatment of multiple myeloma.
Health effects
Ixazomib citrate is an N-capped dipeptidyl leucine boronic acid like bortezomib, and it is able to inhibit the chymotrypsin-like proteolytic site of the 20S proteasome.
Side effects
Common side effects of Ixazomib citrate include diarrhea, constipation and low platelet count. Like the older bortezomib (which can only be given by injection), it acts as a proteasome inhibitor, has orphan drug status in the US and Europe, and is a boronic acid derivative.
in vivo
Ixazomib citrate (MLN9708; 11 mg/kg) significantly inhibits MM tumor growth and prolongs survival in the human plasmacytoma MM.1S xenograft mouse model. The blood chemistry profiles of Ixazomib-treated mice show normal levels of creatinine, hemoglobin, and bilirubin. Ixazomib dramatically increases the number of cleaved-caspase-3 positive cells of the xenograft model[2].
Ixazomib citrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 3868 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8506 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 | sales@sjar-tech.com | China | 504 | 58 |
| Cangzhou Kangrui Pharma Tech Co. Ltd., | +86-18632776803 +86-13833998158 | cangzhoukangrui@126.com | China | 773 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29840 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 | marketing1@neostarunited.com | China | 8830 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9644 | 58 |
View Lastest Price from Ixazomib citrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-22 | Ixazomib Citrate
1239908-20-3
|
US $0.00-0.00 / g | 10g | 99% | 10kgs | Cangzhou Kangrui Pharma Tech Co. Ltd., | |
 |
2025-09-11 | Ixazomib Citrate
1239908-20-3
|
US $0.00 / g | 1g | More Than 99% | 100kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | |
 |
2019-07-06 | Ixazomib citrate (USAN)
1239908-20-3
|
US $1.00 / kg | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Ixazomib Citrate
1239908-20-3
- US $0.00-0.00 / g
- 99%
- Cangzhou Kangrui Pharma Tech Co. Ltd.,
-
- Ixazomib Citrate
1239908-20-3
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
-
- Ixazomib citrate (USAN)
1239908-20-3
- US $1.00 / kg
- 95%-99%
- Career Henan Chemical Co
