5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
- CAS No.
- 1093070-16-6
- Chemical Name:
- 5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide
- Synonyms
- GRL-0617 (GRL0617;5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide;5-Amino-2-Methyl-N-[(1r)-1-Naphthalen-1-Ylethyl]benzamide;(R)-5-Amino-2-methyl-N-(1-(naphthalen-1-yl)ethyl)benzamide;Benzamide, 5-amino-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-;GRL 0617,competitive noncovalent inhibitor,Inhibitor,GRL0617,Deubiquitinase,SARS coronavirus,inhibit,GRL-0617,DUBs,SARS-CoV
- CBNumber:
- CB43085996
- Molecular Formula:
- C20H20N2O
- Molecular Weight:
- 304.39
- MDL Number:
- MFCD12547683
- MOL File:
- 1093070-16-6.mol
| Boiling point | 514.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.168±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in DMSO (>30 mg/mL) and ethanol (15 mg/mL) |
| form | solid |
| pka | 14.26±0.46(Predicted) |
| color | Beige |
| Stability | Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | SQH4947NDN |
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 4575DF | 5-Amino-2-methyl-N-[2-(naphthalen-1-yl)ethyl]benzamide | 1093070-16-6 | 10mg | $218 | 2021-12-16 | Buy |
| ChemScene | CS-0063568 | GRL0617 99.78% | 1093070-16-6 | 10mg | $650 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0000212 | 5-AMINO-2-METHYL-N-(1R-NAPHTHALEN-1-YL-ETHYL)-BENZAMIDE 95.00% | 1093070-16-6 | 10MG | $866.25 | 2021-12-16 | Buy |
| ChemScene | CS-0063568 | GRL0617 99.78% | 1093070-16-6 | 5mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0063568 | GRL0617 99.78% | 1093070-16-6 | 50mg | $2000 | 2021-12-16 | Buy |
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Chemical Properties,Uses,Production
Description
GRL-0617 (1093070-16-6) is a potent (IC50?= 600 nM) noncovalent inhibitor of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). GRL-0617 inhibited SARS-CoV viral replication in Vero E6 cells with no cytotoxicity (EC50?= 15 μM).??Inactive against human DUB-like proteases HAUSP, USP18, UCH-L1, UCH-L3, and PLP2
Definition
ChEBI: GRL-0617 is a benzamide resulting from the formal condensation of the carboxy group of 5-amino-2-methylbenzoic acid with the amino group of (1R)-1-(naphthalen-1-yl)ethan-1-amine. It is a potent noncovalent inhibitor (IC50 = 600 nM) of severe acute respiratory syndrome-coronavirus papain-like protease (SARS-CoV PLpro). It has a role as an anticoronaviral agent and a protease inhibitor. It is a member of naphthalenes, a substituted aniline, a member of benzamides and a secondary carboxamide.
storage
Store at -20°C
References
1)????Ratia?et al. (2008),?A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication;?Proc. Natl. Acad. Sci. USA,?105?16119
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Preparation Products And Raw materials
Raw materials
Preparation Products
5-Amino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| Hunan Jibang Biological Technology Co., LTD | +8613776644403 | sales02@kingboomtech.com | China | 1806 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2994 | 58 |